Electron injection leads to the transition of two-dimensional MoX2 (X = S, Se, and Te) nanosheets from the semiconducting H phase to semimetallic T′ phase.

The Ras-related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family of small guanosine triphosphatases, is critical for many cellular activities, such as phagocytosis, adhesion, migration, motility, cell proliferation, and axonal growth. In addition, RAC1 plays an important role in cancer angiogenesis, invasion, and migration, and it has been reported to be related to most cancers, such as breast cancer, gastric cancer, testicular germ cell cancer, and lung cancer. Recently, the therapeutic target of RAC1 in cancer has been investigated. In addition, some investigations have shown that inhibition of RAC1 can reverse drug-resistance in non-small cell lung cancer. In this review, we summarize the recent advances in understanding the role of RAC1 in lung cancer and the underlying mechanisms and discuss its value in clinical therapy.

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In this paper, we propose a model's sparse representation based on reduced mixed generalized multiscale finite element (GMsFE) basis methods for elliptic PDEs with random inputs. Mixed generalized multiscale finite element method (GMsFEM) is one of the accurate and efficient approaches to solve multiscale problem in a coarse grid with local mass conservation. When the inputs of the PDEs are parameterized by the random variables, the GMsFE basis functions usually depend on the random parameters. This leads to a large number degree of freedoms for the mixed GMsFEM and substantially impacts on the computation efficiency. In order to overcome the difficulty, we develop reduced mixed GMsFE basis methods such that the multiscale basis functions are independent of the random parameters and span a low-dimensional space. To this end, a greedy algorithm is used to find a set of optimal samples from a training set scattered in the parameter space. Reduced mixed GMsFE basis functions are constructed based on the optimal samples using two optimal sampling strategies: basis-oriented cross-validation and proper orthogonal decomposition. Although the dimension of the space spanned by the reduced mixed GMsFE basis functions is much smaller than the dimension of the original full order model, the online computation still depends on the number of coarse degree of freedoms. To significantly improve the online computation, we integrate the reduced mixed GMsFE basis methods with sparse tensor approximation and obtain a sparse representation for the model's outputs. The sparse representation is very efficient for evaluating the model's outputs for many instances of parameters. To illustrate the efficacy of the proposed methods, we present a few numerical examples for multsicale problems with random inputs.Comment: 37 page

Vertically stacking layered metal halide perovskites (MHPs) have emerged as promising semiconductors for optoelectronic applications due to their low cost, tunable band gaps, and excellent stability and solution processability. However,...

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In this paper, we propose a novel variable-separation (NVS) method for generic multivariate functions. The idea of NVS is extended to to obtain the solution in tensor product structure for stochastic partial differential equations (SPDEs). Compared with many widely used variation-separation methods, NVS shares their merits but has less computation complexity and better efficiency. NVS can be used to get the separated representation of the solution for SPDE in a systematic enrichment manner. No iteration is performed at each enrichment step. This is a significant improvement compared with proper generalized decomposition. Because the stochastic functions of the separated representations obtained by NVS depend on the previous terms, this impacts on the computation efficiency and brings great challenge for numerical simulation for the problems in high stochastic dimensional spaces. In order to overcome the difficulty, we propose an improved least angle regression algorithm (ILARS) and a hierarchical sparse low rank tensor approximation (HSLRTA) method based on sparse regularization. For ILARS, we explicitly give the selection of the optimal regularization parameters at each step based on least angle regression algorithm (LARS) for lasso problems such that ILARS is much more efficient. HSLRTA hierarchically decomposes a high dimensional problem into some low dimensional problems and brings an accurate approximation for the solution to SPDEs in high dimensional stochastic spaces using limited computer resource. A few numerical examples are presented to illustrate the efficacy of the proposed methods.keywords: Novel variable-separation , Sparse regularization, Improved least angle regression algorithm, Hierarchical sparse low rank tensor approximation

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