to Indonesia and across the Pacific Islands. The genus is considered to possess activities of detoxification, antiarthritis and abirritation and is used as antidote and demulcent 1. In recent years, several papers have described phytochemistry investigations of A. gramnifolia and was found to be rich in stilbenoids and triterpenes 2-5. Motivated by a search for bioactive compounds from this plant, further chemical investigation were carried out. As a result, a new phenolic compounds (1), together with three known phenols (2-4), were isolated from this plant. In addition, the antitobacco mosaic virus activities of compounds 1-4 were evaluated. This article deals with the isolation, structural elucidation and biological activities of the isolated compounds. EXPERIMENTAL Optical rotations were measured with a Horiba SEPA-300 polarimeter. UV spectra were obtained using a Shimadzu UV-2401A spectrophotometer. A Tenor 27 spectrophotometer was used for scanning IR spectroscopy with KBr pellets. 1 D and 2 D NMR spectra were recorded on DRX-500 spectrometers with TMS as internal standard. Unless otherwise specified, chemical shifts (δ) were expressed in ppm with reference to the solvent signals. HRESIMS was performed on an API QSTAR time-of-flight spectrometer and a VG autospec-3000 spectrometer, respectively. Preparative HPLC was performed

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AJC-15370A new diphenylethylenes, gramniphenol J (1), was isolated from Arundina graminifolia. Its structure was elucidated by spectroscopic methods including extensive 1D-and 2D-NMR techniques. Compound 1 was evaluated for its cytotoxicity against five human tumor cell lines and showed cytotoxicity against PC3 and SHSY5Y cells with IC50 values of 8.2 and 7.6 µM.

A new flavonoid, 3(S),4(S)-3',4'-dihydroxyl-7,8,-methylenedioxylpterocarpan (1), together with ten known flavonoids derivatives (2-11), were isolated from the whole plant of Arundina gramnifolia. The structure of compounds 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was also evaluated for its cytotoxicity against five human tumor cell lines. The results revealed that compound 1 showed high cytotoxicity against HSY5Y cell with IC50 values of 2.2 µM and moderate cytotoxicities with IC50 valves 5-10 µM for other four tested cell lines.

one (3) were isolated from the whole plants of Thalictrum glandulosissimum.Their structures were elucidated by spectroscopic methods, including extensive 1 H, 13 C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity. Compounds 1-3 exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 17.6, 15.0, and 23.6 respectively.The genus Thalictrum belongs to the subfamily Thalictroideae of Ranunculaceae and consists of the subgenera Thalictrum and Lecoyerium. 1,2 This genus has around 200 species, which are distributed in Asia, Europe, Africa, North America, and South America. Around 67 species are recorded in the flora of China, and the majority of which are found in Southwest China. At least 43 species of this genus are used medicinally in China. 2,3 This genus is also well known for its diverse pharmacological activities, including anti-tumor, anti-virus, anti-microbial, anti-tuberculosis, anti-inflammatory, anti-malarial activities, and the like, 4 and the main active ingredients found in this genus are alkaloids, 5-7 flavonoids, 8,9 triterpenoid saponins, 10,11 lithospermoside, 12 and the like.Thalictrum glandulosissimum is a herbaceous plant of Thalictrum genus with short rhizome and many thick fibrous roots. It distributed in Dali, Heqing, and Binchuan Prefecture, Yunnan Province, and grows on the hillside grassland at an altitude of 2500 meters. 2 The whole plants of T. glandulosissimum are used to treat some diseases, such as enteritis, dysentery, jaundice and throat by Bai nationality people in Yunnan Province of China, and the alkaloids are the main active components in this plants. 3,7,13,14 In the