to Indonesia and across the Pacific Islands. The genus is considered to possess activities of detoxification, antiarthritis and abirritation and is used as antidote and demulcent 1. In recent years, several papers have described phytochemistry investigations of A. gramnifolia and was found to be rich in stilbenoids and triterpenes 2-5. Motivated by a search for bioactive compounds from this plant, further chemical investigation were carried out. As a result, a new phenolic compounds (1), together with three known phenols (2-4), were isolated from this plant. In addition, the antitobacco mosaic virus activities of compounds 1-4 were evaluated. This article deals with the isolation, structural elucidation and biological activities of the isolated compounds. EXPERIMENTAL Optical rotations were measured with a Horiba SEPA-300 polarimeter. UV spectra were obtained using a Shimadzu UV-2401A spectrophotometer. A Tenor 27 spectrophotometer was used for scanning IR spectroscopy with KBr pellets. 1 D and 2 D NMR spectra were recorded on DRX-500 spectrometers with TMS as internal standard. Unless otherwise specified, chemical shifts (δ) were expressed in ppm with reference to the solvent signals. HRESIMS was performed on an API QSTAR time-of-flight spectrometer and a VG autospec-3000 spectrometer, respectively. Preparative HPLC was performed
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