A uracil‐based heterocyclic azo derivative was prepared by coupling diazotized 5‐aminouracil with 2‐naphthol. This ligand, viz., 1‐(2,4‐dioxopyrimidine‐5‐yl)‐azo‐naphth‐2‐ol (HNAP), was used as a precursor for the synthesis of a series of complexes with manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) ions. Various physicochemical measurements UV–Visible, Infrared (IR), 1H NMR, 13C Nuclear Magnetic Resonance (NMR), and electron spin resonance (ESR) spectral studies were employed to characterize the ligand and the metal complexes. The ligand showed good selectivity toward Mn2+ over the other metal ions with a detection limit of 1.36 μM. This probe was used for the confocal fluorescence imaging of Mn2+ ions in Michigan Cancer Foundation‐7 (MCF‐7) cells. The ligand and the metal complexes were tested for their cytotoxicity on the MCF‐7 cell line. It was observed that complexation of HNAP with the metal ions exhibited a promising cytotoxicity.

A novel heterocyclic ligand, viz. 1,2-dihydro-1,5-dimethyl-4-[[1-2--oxo-2H-1-benzopyran-3-yl)ethylidene]amino]-2-phenyl-3H-pyrazol-3-one, was prepared by condensing 3-acetylcoumarin with 4-aminoantipyrine. This ligand is versatile in forming complexes with lanthanum(III), praseodymium(III), samarium(III), gadolinium(III) and dysprosium(III) ions. The ligand and the metal complexes were characterized through various physicochemical and spectral studies. The spectral studies revealed that the ligand is coordinated to the metal ion in a bidentate fashion, through the azomethine nitrogen and the oxygen atom of the pyrazolone ring. The powder XRD patterns of ligand and the dysprosium(III) complex were studied. The photoluminescent properties of ligand and metal complexes were evaluated and the relative quantum yields were determined. It was observed that in all cases the metal ions enhanced the luminescence intensity. The α-amylase inhibitory activity of the ligand and the metal complexes was evaluated using the method of Apostolidis. The metal complexes exhibited increased activity compared to the ligand. The antioxidant property was also examined using the DPPH assay and the metal complexes were found to be more potent antioxidants than the ligand.

A heterocyclic Schiff base was prepared by condensing 3‐acetylcoumarin with 2‐amino‐3‐carboxyethyl‐4,5,6,7‐tetrahydrobenzo[b]thiophene. Such Schiff bases derived from two different heterocyclic moieties are rare and expected to have properties surpassing those of either of the parent compounds in effectiveness of complex formation and biological activities. This ligand formed a series of complexes with manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) ions. The ligand and the metal complexes were characterized by various physicochemical and spectral studies. These included elemental analysis, molar conductance, magnetic susceptibility, as well as UV–vis, IR, 1H NMR, 13C NMR, and ESR spectral studies. The ESR spectral data adequately supported the covalent nature of the metal–ligand bonds. The ligand possessed a hexagonal crystal structure, but on complexation the crystallinity was lost. The fluorescence spectra of the ligand and its metal complexes in DMSO were also recorded. The ligand and the metal complexes were screened for their antimicrobial activities, and it was observed that the metal complexes are more active than the ligand. The α‐amylase inhibitory activity and the DNA cleavage activity of the ligand and the metal complexes were also examined. in vitro antitumor activity of the copper(II) complex was assayed against human cervical carcinoma cells (HeLa cell line), showing that the complex exhibited promising antitumor activity on the HeLa cell line.

A novel potentially tridentate Schiff base has been prepared by condensing antipyrine-4-carboxaldehyde with 2-aminophenol. This ligand formed a series of complexes with cobalt(II), nickel(II), copper(II) and zinc(II) ions. The ligand and the metal complexes were characterized through various physicochemical and spectral studies. These studies include elemental analysis, molar conductance, magnetic susceptibility, UV-Vis, IR, 1 H NMR, mass and ESR spectral studies. The ESR spectral data revealed that the metal-ligand bonds have considerable covalent characters. The XRD profile of the ligand and the cobalt(II) complex indicated a hexagonal crystal structure. The fluorescence spectra of the ligand and its metal complexes in DMSO were also recorded. The copper(II) metal complex was subjected to thermal decomposition study.

Synthesis of NS1 and NS2 peptide fragment of hepatitis C virus polyprotein was carried out on a terpolymer- polystyrene, N-vinylpyrrolidone, 1,6-hexanediol diacrylate resin (PS-NVP-HDDA). The radical aqueous suspension polymerisation resulted in the resin, that exhibited high swelling capacity in various solvents. The peptides were synthesized step-wise by Fmoc strategy, established with amino acid analysis and purified using HPLC. The polymer's high degree of swelling might facilitate free reagent interaction with resin-bound functional sites, resulting in an increased rate of amide bond production. The peptides yield and purity obtained from new support was high when compared to Merrifield resin. These peptides synthesis depicts the application of PS-NVP-HDDA resin developed for synthesis of long chain peptides in high homogeneity and high yield.