Coupling reactions form an important class of reactions in organic synthesis and these reactions are usually catalysed by metals and are of great significance. Copper due to its versatility and low toxicity has always gained much attention. This first review on copper‐catalysed amination of aryl and heteroaryl halides summarises the developments in this area and covers literature upto 2019.
The asymmetricM annichr eactioni savery important method for CÀCb ond formation,a nd it is the classical method for the preparation of b-amino ketones and aldehydes. The resulting b-amino carbonyl compounds are widely found in nature, which attests to the importance of this reaction. This Focus Review providesa no verview of asymmetricM annich reactions, the various catalysts that have been used, and its applications,f or papers published since 2013.
Scheme1.The Mannich reaction.Scheme2.The mechanism of the Mannich reaction;reproduced with permissionfrom Ref.[1]. andhi University. His research interests are in the areaso fo rganic synthesis, medicinal chemistry,a nd catalysis, in particularr uthenium-, iron-, zinc-, and copper-catalyzedr eactions. His h-index is 24.
Quinolines are predominant class of nitrogen containing heterocycles with wide applications in medicinal and industrial fields. Owing to their significant importance, numerous synthetic protocols have emerged in the past two...
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