Recent advances and prospects in the metal-free synthesis of quinolines

Abstract

Quinolines are predominant class of nitrogen containing heterocycles with wide applications in medicinal and industrial fields. Owing to their significant importance, numerous synthetic protocols have emerged in the past two...

Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules

“… 3 The quinoline scaffold has even been described as a “privileged structure”, since members of this structural class are able to interact with different types of bioactive targets and have attracted the interest of investigators in a broad spectrum of sciences from chemistry and biology to medicine. 4 Hence, introducing quinoline derivatives into bioactive molecules in the late-stage functionalization of natural products and drugs under mild conditions is of equal importance to the direct synthesis of quinolines in the field of chemical biology and pharmacology. Achieving these two goals in one simple operation would have great appeal.…”

Recent Applications of Quinolinium Salts in the Synthesis of Annulated Heterocycles

“…In addition, a number of novel strategies including transition-metal-catalyzed reactions have also been developed in recent years. 31 32…”

Base‐Catalyzed Intramolecular Self‐Cyclization of o‐Alkenylaryl Isocyanides: Access to 4‐Cyano‐3‐arylquinolines

“…[7] Aomong them, intramolecular selfcyclization is one of the most efficient methods of synthesizing polyfunctionalized quinolines featured high atom economy, however, very limited efforts were reported. [8] Thus, the development of efficient and general strategies for the construction of quinolines is highly desirable.…”