A uracil‐based heterocyclic azo derivative was prepared by coupling diazotized 5‐aminouracil with 2‐naphthol. This ligand, viz., 1‐(2,4‐dioxopyrimidine‐5‐yl)‐azo‐naphth‐2‐ol (HNAP), was used as a precursor for the synthesis of a series of complexes with manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) ions. Various physicochemical measurements UV–Visible, Infrared (IR), 1H NMR, 13C Nuclear Magnetic Resonance (NMR), and electron spin resonance (ESR) spectral studies were employed to characterize the ligand and the metal complexes. The ligand showed good selectivity toward Mn2+ over the other metal ions with a detection limit of 1.36 μM. This probe was used for the confocal fluorescence imaging of Mn2+ ions in Michigan Cancer Foundation‐7 (MCF‐7) cells. The ligand and the metal complexes were tested for their cytotoxicity on the MCF‐7 cell line. It was observed that complexation of HNAP with the metal ions exhibited a promising cytotoxicity.

Alkaloids U 0600Synthesis and Cytotoxicity Studies of Thiazole Analogues of the Anticancer Marine Alkaloid Dendrodoine. -Among a variety of dendrodoine analogues, the derivative (IIIc) shows significant in vitro cytotoxicity against a panel of human cancer cell lines. -(REJI, T. F. A. F.; DEVI, S. K. C.; THOMAS, K. K.; SREEJALEKSHMI, K. G.; MANJU, S. L.; FRANCIS, M.; PHILIP, S. K.; BHARATHAN, A.; RAJASEKHARAN*, K. N.; Indian J. Chem.

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A novel heterocyclic ligand, viz. 1,2-dihydro-1,5-dimethyl-4-[[1-2--oxo-2H-1-benzopyran-3-yl)ethylidene]amino]-2-phenyl-3H-pyrazol-3-one, was prepared by condensing 3-acetylcoumarin with 4-aminoantipyrine. This ligand is versatile in forming complexes with lanthanum(III), praseodymium(III), samarium(III), gadolinium(III) and dysprosium(III) ions. The ligand and the metal complexes were characterized through various physicochemical and spectral studies. The spectral studies revealed that the ligand is coordinated to the metal ion in a bidentate fashion, through the azomethine nitrogen and the oxygen atom of the pyrazolone ring. The powder XRD patterns of ligand and the dysprosium(III) complex were studied. The photoluminescent properties of ligand and metal complexes were evaluated and the relative quantum yields were determined. It was observed that in all cases the metal ions enhanced the luminescence intensity. The α-amylase inhibitory activity of the ligand and the metal complexes was evaluated using the method of Apostolidis. The metal complexes exhibited increased activity compared to the ligand. The antioxidant property was also examined using the DPPH assay and the metal complexes were found to be more potent antioxidants than the ligand.

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