Hydrogels are physically or chemically cross-linked polymer networks that are able to absorb large amounts of water. They can be classified into different categories depending on various parameters including the preparation method, the charge, and the mechanical and structural characteristics. The present review aims to give an overview of hydrogels based on natural polymers and their various applications in the field of tissue engineering. In a first part, relevant parameters describing different hydrogel properties and the strategies applied to finetune these characteristics will be described. In a second part, an important class of biopolymers that possess thermosensitive properties (UCST or LCST behavior) will be discussed. Another part of the review will be devoted to the application of cryogels. Finally, the most relevant biopolymer-based hydrogel systems, the different methods of preparation, as well as an in depth overview of the applications in the field of tissue engineering will be given.
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.
In modern technology, there is a constant need to solve very complex problems and to fine-tune existing solutions. This is definitely the case in modern medicine with emerging fields such as regenerative medicine and tissue engineering. The problems, which are studied in these fields, set very high demands on the applied materials. In most cases, it is impossible to find a single material that meets all demands such as biocompatibility, mechanical strength, biodegradability (if required), and promotion of cell-adhesion, proliferation, and differentiation. A common strategy to circumvent this problem is the application of composite materials, which combine the properties of the different constituents. Another possible strategy is to selectively modify the surface of a material using different modification techniques. In the past decade, the use of nonthermal plasmas for selective surface modification has been a rapidly growing research field. This will be the highlight of this review. In a first part of this paper, a general introduction in the field of surface engineering will be given. Thereafter, we will focus on plasma-based strategies for surface modification. The purpose of the present review is twofold. First, we wish to provide a tutorial-type review that allows a fast introduction for researchers into the field. Second, we aim to give a comprehensive overview of recent work on surface modification of polymeric biomaterials, with a focus on plasma-based strategies. Some recent trends will be exemplified. On the basis of this literature study, we will conclude with some future trends for research.
Concrete cracks due to its low tensile strength. The presence of cracks endangers the durability as they generate a pathway for harmful particles dissolved in fluids and gases. Without a proper treatment, maintenance costs will increase. Self-healing can prevail in small cracks due to precipitation of calcium carbonate and further hydration. Therefore, the use of microfibres is proposed to control the crack width and thus to promote the self-healing efficiency. In the current research, crack sealing is also enhanced by the application of superabsorbent polymers. When cracking occurs, superabsorbent polymers are exposed to the humid environment and swell. This swelling reaction seals the crack from intruding potentially harmful substances. Mortar mixtures with microfibres and with and without superabsorbent polymers were investigated on their crack sealing and healing efficiency. Regain in mechanical properties upon crack healing was investigated by the performance of four-point-bending tests, and the sealing capacity of the superabsorbent polymer particles was measured through a decrease in water permeability. In an environment with a relative humidity of more than 60%, only samples with superabsorbent polymers showed healing. Introducing 1 m% of superabsorbent polymer gives the best results, considering no reduction of the mechanical properties in comparison to the reference, and the superior self-sealing capacity.
In the present work, 3D CAD scaffolds for tissue engineering applications were developed starting from methacrylamide-modified gelatin (GelMOD) using two-photon polymerization (2PP). The scaffolds were cross-linked employing the biocompatible photoinitiator Irgacure 2959. Because gelatin is derived from collagen (i.e., the main constituent of the ECM), the developed materials mimic the cellular microenvironment from a chemical point of view. In addition, by applying the 2PP technique, structural properties of the cellular microenvironment can also be mimicked. Furthermore, in vitro degradation assays indicated that the enzymatic degradation capability of gelatin is preserved for the methacrylamide-modified derivative. An in depth morphological analysis of the 2PP-fabricated scaffolds demonstrated that the parameters of the CAD model are reproduced with great precision, including the ridge-like surface topography on the order of 1.5 μm. The developed scaffolds showed an excellent stability in culture medium. In a final part of the present work, the suitability of the developed scaffolds for tissue engineering applications was verified. The results indicated that the applied materials are suitable to support porcine mesenchymal stem cell adhesion and subsequent proliferation. Upon applying osteogenic stimulation, the seeded cells differentiated into the anticipated lineage. Energy dispersive X-ray (EDX) analysis showed the induced calcification of the scaffolds. The results clearly indicate that 2PP is capable of manufacturing precisely constructed 3D tissue engineering scaffolds using photosensitive polymers as starting material.
Besides their use as packaging materials, biodegradable polymers can play a major role in tissue engineering as three‐dimensional porous structures (scaffolds). The success of these biodegradable scaffolds is, however, determined by the response it elicits from the surrounding biological environment and this response is governed, to a large extent, by the surface characteristics of the scaffold. Multiple approaches have been developed to obtain the desired surface properties, however, in the past decade, the use of non‐thermal plasmas for selective surface modification has been a rapidly growing research field. This paper therefore presents a critical overview on recent advances in plasma‐assisted surface modification of biodegradable polymers.
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