Chemical construction of molecularly organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.

Hybridization produces the better: Colloidal hollow periodic mesoporous organosilica nanoparticles (HPMO NPs) with tunable compositions and highly hybridized nanostructures are successfully synthesized by a simple, easily scale-up but versatile silica-etching chemistry (alkaline or HF etching) for their applications in nano-fabrication and nano-medicine.

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Hierarchical nanoscale multi-shell Au/CeO2 hollow spheres with interconnected nanochambers and high catalytic activity were synthesized using a controllable approach.

4386www.MaterialsViews.com wileyonlinelibrary.com strategy for the successful cancer treatment. [ 2 ] On the one hand, stimuli-responsive drug delivery systems (DDSs) can realize the on-demand drug release triggered by inner physiological changes (pH, redox, enzyme, competitive binding, etc.) and/or external irradiations (light, magnetic, electronic fi eld, ultrasound, etc.), thus the side-effects caused by toxic drugs to normal tissues can be effectively mitigated and the therapeutic effi cacy against cancer cells can be signifi cantly enhanced. [ 3 ] On the other hand, stimuli-enhanced diagnostic imaging, such as magnetic resonance imaging (MRI), ultrasonography, fl uorescence, and so on, can effectively improve the imaging performances of contrast agents (CAs) for accurate tumor imaging and detection. [ 4 ] However, the construction of multifunctional nanosystems with concurrent multiple stimuli-responsive drug release and diagnostic imaging still remains a great technical challenge though it is of substantial signifi cance for realizing the simultaneous diagnostic imaging and therapy (designated as theranostic) for successful cancer treatments. Exfoliated graphene oxide (GO) nanosheets, a parent material of graphene with unique free-standing two-dimensional crystallized structure and one-atom thickness, has been extensively explored in drug delivery, [ 5 ] gene transportation, [ 6 ] molecular imaging, [ 7 ] biosensing [ 8 ] and photothermal/photodynamic therapy, [ 9 ] mainly due to its high biocompatibility and unique physical/chemical properties such as excellent aqueous processability, abundant surface chemistry, near-infrared light Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe 3 O 4 and paramagnetic MnO x nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and effi cient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interactwith GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnO x NPs can disintegrate in mild acidic and reduction environment to realize the highly effi cient pH-responsive and reduction-triggered T 1weighted magnetic resonance imaging (MRI). Superparamagnetic Fe 3 O 4 NPs can not only function as the T 2 -weighted contrast agents for MRI, but also response to the external magnetic fi eld for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loa...

HIGHLIGHTS• Nanoscale multi-dimensional heterojunctions in situ grow at the edge of two-dimensional MXene conductive network.• A controlled anneal procedure in 150 °C is for preparing anatase TiO 2 /SnO 2 heterojunctions with oxygen vacancy scramble effect.• The perovskite solar cells achieve high power conversion efficiency and high moisture-resistance stability.ABSTRACT A multi-dimensional conductive heterojunction structure, composited by TiO 2 , SnO 2 , and Ti 3 C 2 T X MXene, is facilely designed and applied as electron transport layer in efficient and stable planar perovskite solar cells.Based on an oxygen vacancy scramble effect, the zero-dimensional anatase TiO 2 quantum dots, surrounding on two-dimensional conductive Ti 3 C 2 T X sheets, are in situ rooted on three-dimensional SnO 2 nanoparticles, constructing nanoscale TiO 2 /SnO 2 heterojunctions. The fabrication is implemented in a controlled lowtemperature anneal method in air and then in N 2 atmospheres. With the optimal MXene content, the optical property, the crystallinity of perovskite layer, and internal interfaces are all facilitated, contributing more amount of carrier with effective and rapid transferring in device. The champion power conversion efficiency of resultant perovskite solar cells achieves 19.14%, yet that of counterpart is just 16.83%. In addition, it can also maintain almost 85% of its initial performance for more than 45 days in 30-40% humidity air; comparatively, the counterpart declines to just below 75% of its initial performance.

Endoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity. For the first of time, this study presents the design and construction of a fluorescent endoscopic system that harnesses the power of the second near‐infrared window II (NIR‐II) fluorescence imaging. An NIR‐II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev‐ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR‐II endoscopy imaging system. Simultaneous NIR‐II fluorescence and white‐light (WL) imaging of VEGF is validated in an orthotopic rat colorectal cancer model. This NIR‐II endoscopy system is a generalizable design, and it is compatible with the most of current clinic endoscopies. Similar hardware upgrades are expected to greatly promote the application of NIR‐II fluorescent imaging in the clinic.

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