Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles

Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles

“…For example, several vitamin E derivatives have been found to enhance the therapeutic effect of anticancer drugs by reducing the transmembrane potential of mitochondria and thereby suppressing their ATP-producing activity [20][21][22]. Owing to this remarkable property of the vitamin E derivatives, they have been used as functional excipients for the controlled delivery of several kinds of anticancer drugs [20,[23][24][25]. However, the co-administration of vitamin E derivatives with anticancer drugs to reverse drug resistance has rarely been exploited.…”

Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models

“…Colorectal carcinoma causes approximately 50,000 deaths in the United States and 655,000 deaths throughout the world per year [4,5]. Breast cancer is the most common malignancy in women, with one in nine women developing breast cancer during their lifetime [6] and cancer death with more than a million newly diagnosed cases annually worldwide [3]. Surgical resection in combination with adjuvant therapy is efficient at the early stages of disease, but subsequent relapse and metastasis often occur.…”

Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel

“…It was worth noting that the total siRNA amount in PSTs was the same as PSs or PTs, but the influences of PSTs on cell migration and invasion were more remarkable than that of PSs and PTs, indicating that the knockout of Snail and Twist at the same time was better at inhibiting cell longitudinal motility than knocking out a single protein. To simulate the in vivo environment, the invasion assay was performed, which requires a cell to migrate through an extracellular matrix (ECM) barrier by first enzymatically degrading the barrier and then settle at a new location [39]. The results showed the similar trend as the migration assay, but better inhibitory effect.…”