Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyaksan (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum chuanxiong Hort., Paeonia lactiflora pall., Poria cocos (Schw.) Wolf, Alisma orientalis (Sam.) Juzep., Atractylodes macrocephala Koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. Recent studies show that DSS has an effect on free radical-mediated neurological diseases and exhibits anti-inflammatory and antioxidant activities and reduces cell apoptosis in the hippocampus. In addition, DSS mediates the modulation of central monoamine neurotransmitter systems and ameliorates dysfunction of the central cholinergic nervous system and scopolamine-induced decrease in ACh levels. DSS improves the function of the dopaminergic, adrenergic, and serotonergic nervous systems. Interestingly, DSS can alleviate cognitive dysfunction of Alzheimer's disease (AD) patients, suggesting that it is a useful therapeutic agent for AD. This paper reviews the mechanism of DSS for the treatment of AD.
The nature of polyolefin branch-block copolymers produced using mixed-metallocene catalysts has been further characterized in an attempt to relate polymer microstructure to properties. These copolymers were synthesized by incorporating vinyl-terminated, crystallizable macromonomers into amorphous backbones. It was shown that polymer properties depended strongly on the fine details of the polymerization procedure (sequential or ex-situ vs simultaneous or in-situ). Here we present rheological, chromatographic, and thermal data along with polymerization kinetic model simulations to interpret the observed property differences between ex-situ and in-situ produced polymers.
The effects of weakly coupled plasmas on the dynamic dipole polarizabilities of the H− and Ps− ions are investigated using highly correlated exponential wave functions. The Debye-Hückel shielding approach of plasma modeling is used to represent weakly coupled plasma environments. In free-atomic cases, results obtained from the present study for H− are in agreement with the available calculations and results for Ps − are reported for the first time. Frequency-dependent polarizabilities of H− and Ps− as functions of screening parameter are also presented for the first time.
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