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Biocompatible nanocarriers conjugated with magnetic nanoparticle, doxorubicin and poly(ethylene oxide) (PEG) motif have been designed (PVLPEG-PVLDOXI-PCL-PHOS) to create a magnetic vector under magnetic field. Acylhydrazine linker is used to release the drug exactly at the mild acidic conditions resembling the pH of the cancerous cells. All the monomers and polymers are characterized carefully by the routine analytical techniques. Thermogravimetric analysis (TGA), FT-IR spectroscopy and scanning electron microscope (SEM) techniques are employed to confirm the anchoring of iron particle (Fe 3 O 4 ) to the PVLPEG-PVLDOXI-PCL-PHOS. Reservoir capabilities of the newly designed biodegradable nanocarrier are tested by both dynamic light scattering (DLS) and transmission electron microscopy (TEM). Drug release profile from nanocarrier is monitored by fluorimeter. The release profile shows the importance of having the acylhydrazine linker that helps to release the drug at the mild acidic conditions similar to cancerous cells. Confocal laser scanning microscopy (CLSM) and flow cytometry studies on 4T cells indicate that nanocarriers from PVLPEG-PVLDOXI-PCL-PHOS polymer are internalized efficiently. It is very interesting to note that the nanocarriers have exhibited both biologically and magnetically targeting abilities toward 4T cells in vitro.

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Poly(ethylene glycol) functionalized with tetra-acetylene (PTETACT) and pentaerythritol (3-mercaptopropionic acid) (PETM) are cross-linked by a thiol–yne reaction to create robust, tuneable networks.

The newly developed polymeric nanocarrier could open a new avenue for cancer therapy, due to its unique design as well as, most importantly, its biocompatible and biodegradable nature.

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Mercury (Hg 2+ )-triggered desulfurization of 1,3dithiolane to the formyl group formation process has been utilized here to develop a norbornene-based reaction-triggered ESIPT active probe (NT). Mercury (Hg 2+ ) activated the excited-state proton transfer (ESIPT) process of both NT and its water-soluble polymer Poly-PEG-NT to change the emission from colorless to cyan-green. Due to the Hg 2+ -sensitive reaction site, NT and Poly-PEG-NT serve as highly selective and ultrafast detection systems with a limit of detection (LOD) of 8.2 nM and 107 nM, respectively. Additionally, NT can detect the organic mercury species (CH 3 Hg + ) with a quick response time and an impressive LOD of 1.1 μM. Due to the water-soluble nature of Poly-PEG-NT, it has the capability of detecting Hg 2+ in pure aqueous meda. Both these probes are capable of detecting Hg 2+ in both environmental and biological systems with excellent efficiency. Overall, the easy synthesis, cost-effectiveness, ultrafast detection, high selectivity, and sensitivity of NT and Poly-PEG-NT toward Hg 2+ /CH 3 Hg + can be used for practical purposes with efficiency to counter mercury toxicity.

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