Polycarbonate-based biodegradable copolymers for stimuli responsive targeted drug delivery

Abstract

The newly developed polymeric nanocarrier could open a new avenue for cancer therapy, due to its unique design as well as, most importantly, its biocompatible and biodegradable nature.

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

“…† We chose polycarbonate in this study because polycarbonate is a biocompatible polymer and has been widely used in bone/organ repairing, drug delivery, and tissue regenerative engineering. [40][41][42][43][44][45][46] Note all these applications are in vivo, besides those, we would like to mention the polycarbonate is a polymer that has been used widely in daily applications, such as covers for cell phones, a great example of skin contact without any toxicity or side-effect. The rst set was Fig.…”

Recent Progress and Advances in Stimuli-Responsive Polymers for Cancer Therapy

“…The polymer conjugate accumulated efficiently at the tumor site and showed high antitumor efficacy. In another work, Ganivada et al reported a copolymer using ring-opening polymerization (ROP) and click chemistry for site-specific sustained delivery of the antitumor drug DOX (Ganivada et al, 2016 ). DOX was attached to the polymer via an oxime linker.…”

Click Chemistry in Functional Aliphatic Polycarbonates

“…In 2009, Ji et al developed a pH‐sensitive polymeric prodrug in which DOX was connected to the polycarbonate backbone by hydrazone bonds . The other example of amphiphilic polycarbonate conjugates of doxorubicin with pH‐sensitive hydrazone linker was reported by He et al Recently, Shunmugamet al reported a pH‐responsive nanocarrier in which DOX was conjugated to the polycarbonate backbone by oxime bonds . Wooley et al provided aldehyde‐functionalized polycarbonates that were a potential platform for transformation into various active materials via oxime bonds .…”

“…[72] The other example of amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker was reported by He et al [107] Recently, Shunmugamet al reported a pH-responsive nanocarrier in which DOX was conjugated to the polycarbonate backbone by oxime bonds. [42] Wooley et al provided aldehyde-functionalized polycarbonates that were a potential platform for transformation into various active materials via oxime bonds. [108] Yang et al synthesized amphiphilic block copolymers with aldehyde groups by ring-opening polymerization of a functionalized cyclic carbonate monomer using PEG as the initiator and the copolymers were covalently conjugated with DOX via a pH-sensitive Schiff-base linkage, as shown in Scheme 8.…”

“…Amphiphilic block copolymer PEG‐ b ‐PMPC could be used to construct redox‐responsive, core‐crosslinked micelles via click reaction with the addition of bis‐(azidoethyl) disulfide . Other alkyne‐containing cyclic carbonate monomers such as 5‐methyl‐5‐propargyl‐1,3‐dioxan‐2‐one, 5,5‐di(propargyl)‐1,3‐dioxan‐2‐one, and methyl‐2‐ O ‐ethyloxycarbonyl‐3‐ O ‐propargyloxycarbonyl‐4,6‐ O ‐carbonyl‐α‐ d ‐glucopyranoside were also reported for the preparation of reduction‐sensitive polymeric prodrug, tumor‐targeting polymeric nanocarriers, and functional sugar‐based polymers, respectively. These alkyne‐containing cyclic carbonate monomers are capable of improving the property of aliphatic polycarbonates such as on‐demand drug release, high intracellular doxorubicin accumulation at cancer cells, and low cytotoxicity.…”