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Microwave Irradiation. -A variety of imines (37 examples in all) is prepared in high yields by a microwave-assisted procedure using NaHSO4·SiO2 as an efficient heterogeneous catalyst. -(GOPALAKRISHNAN*, M.; SURESHKUMAR, P.; KANAGARAJAN, V.; THANUSU, J.; GOVINDARAJU, R.; J.

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This synthesis of imines has been carried out efficiently by the condensation of carbonyl compounds with amines in the presence of silica gel supported sodium hydrogen sulfate (NaHSO4.SiO2) as a heterogeneous catalyst under microwave irradiation in solvent-free conditions. NaHSO4.SiO2 can be recovered and re-used up to ten times by simple washing with diethyl ether after each use and activated in an oven at 120 °C for 1 h, thus rendering the process more economical.

A novel class of 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazoles 25-32 were synthesized and evaluated for their in vitro antibacterial and antifungal activities. Four Compounds, which all possessed electron withdrawing functional groups (ZCl, ZNO 2 , ZBr) 27, 28, 30 and 32 were more potent against the tested bacterial/fungal strains than the standard bacterial and fungal drugs ciprofloxacin and fluconazole respectively.