Aluminium metal powder (atomized) catalyzed Friedel–Crafts acylation in solvent-free conditions: A facile and rapid synthesis of aryl ketones under microwave irradiation

Chemopreventive potential of 3-[2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino]-2-thioxoimidazolidin-4-one on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis

“…There is therefore a need to identify synthetic compounds that have significant chemopreventive potential. In view of our continued interest in the development of simpler and more convenient synthetic routes for achieving the biologically challenging hybrid heterocyclic systems [23][24][25][26][27][28][29][30][31] and as part of our ongoing research programme, we have designed a system, which combines both bioactive thiohydantoin and piperidone nuclei together to give a compact structure like the title compound, 3-(2,6-bis(4-fluorophenyl)-3-methylpiperin-4-ylidene)-2-thioxoimidazolidin-4-one and we investigated the effects of 3-(2,6-bis(4-fluorophenyl)-3-methylpiperin-4 -ylidene)-2-thioxoimidazolidin-4-one in a hamster buccal pouch carcinogenesis model using lipid peroxidation, GSH, GP x , GST and GGT as biochemical end points of chemoprevention.…”

A straightforward route to obtain 13C1-labeled clenbuterol

“…In fact, there are only few examples employing aniline or acetanilide as substrates in order to obtain the corresponding acetophenone derivatives. Thus, ZrO 2 and acetyl chloride at 60ºC, 19 aluminum metal powder 20 or zinc 21 with acetyl chloride under microwave conditions, and Ga(OTf) 3 with acetic anhydride at 50ºC 22 have been used to perform this specific transformation. Unfortunately, in our hands most of these procedures did not work although several conditions were tried (see Supporting Information).…”

A facile microwave assisted green chemical synthesis of novel piperidino 2-thioxoimidazolidin-4-ones and theirin vitromicrobiological evaluation

“…The coupling of microwave irradiation together with solid supports under solvent free conditions have received considerable attention recently as it is one of the novel approaches to eco-friendly chemistry. Heterogeneous reactions [6][7][8][9][10][11] facilitated by supported reagents on various mineral oxides have received special attention in recent years.…”