Design, ‘one-pot’ synthesis, characterization, antibacterial and antifungal activities of novel 6-aryl-1,2,4,5-tetrazinan-3-thiones in dry media

Chemopreventive potential of 3-[2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino]-2-thioxoimidazolidin-4-one on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis

“…There is therefore a need to identify synthetic compounds that have significant chemopreventive potential. In view of our continued interest in the development of simpler and more convenient synthetic routes for achieving the biologically challenging hybrid heterocyclic systems [23][24][25][26][27][28][29][30][31] and as part of our ongoing research programme, we have designed a system, which combines both bioactive thiohydantoin and piperidone nuclei together to give a compact structure like the title compound, 3-(2,6-bis(4-fluorophenyl)-3-methylpiperin-4-ylidene)-2-thioxoimidazolidin-4-one and we investigated the effects of 3-(2,6-bis(4-fluorophenyl)-3-methylpiperin-4 -ylidene)-2-thioxoimidazolidin-4-one in a hamster buccal pouch carcinogenesis model using lipid peroxidation, GSH, GP x , GST and GGT as biochemical end points of chemoprevention.…”

A facile microwave assisted green chemical synthesis of novel piperidino 2-thioxoimidazolidin-4-ones and theirin vitromicrobiological evaluation

“…Silica gel supported sodium hydrogen sulphate (NaHSO 4 .SiO 2 ), is a non-toxic and inexpensive catalyst, which has been used for a variety of organic transformations [7,[9][10][11]. Baliah et al have reviewed the importance of piperidin-4-ones as intermediates in the synthesis of several physiologically active compounds [12,13].…”

“…The coupling of microwave irradiation together with solid supports under solvent free conditions have received considerable attention recently as it is one of the novel approaches to eco-friendly chemistry. Heterogeneous reactions [6][7][8][9][10][11] facilitated by supported reagents on various mineral oxides have received special attention in recent years.…”

A Facile Entry for One-pot Synthesis of 5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles

“…20 Owing to our interest in synthesizing fascinating pharmacological and therapeutic important compounds under solid-state reactions, 21,22 we report now to use silica gel supported sodium hydrogen sulphate (NaHSO …”