A Facile Entry for One-pot Synthesis of 5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles

A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.

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Synthesis and anticandidiasis activity of novel (2E)-ethyl-2-(2-(2,4-dinitrophenyl)hydrazono)-4(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates

Kanagarajan

Gopalakrishnan

2010

Pharm Chem J

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In a search for new leads towards potent antifungal agents against candidiasis, a series of novel (2E)-ethyl-2-(2-(2,4-dinitrophenyl)hydrazono)-4-(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates 17 -24 is synthesized and characterized by their physical and analytical data. In vitro microbiological evaluations for all the newly synthesized compounds against clinically isolated Candida sp. are carried out, and their structure-activity effect is discussed.

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A Facile Entry for One-pot Synthesis of 5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles

Cited by 10 publications

References 19 publications

A Facile Microwave‐Assisted “One‐Pot” Synthesis of Piperazino Pyrimidinyl Acetamides, a Class of Hybrid Bis Heterocycles and Their Structural Elucidation Using NMR Spectral Techniques

A Facile Microwave‐Assisted “One‐Pot” Synthesis of Piperazino Pyrimidinyl Acetamides, a Class of Hybrid Bis Heterocycles and Their Structural Elucidation Using NMR Spectral Techniques

Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones

Synthesis and anticandidiasis activity of novel (2E)-ethyl-2-(2-(2,4-dinitrophenyl)hydrazono)-4(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates

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