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In 1940, Griffiths and Tauber (13) published a preliminary account of attempts to devise a physiological salt solution for the isolated foregut of the American roach, Periplaneta americana L. Initially, they tested insect physiological solutions which were recommended by B~l~r (2), Hobson (16), Yeager (25), TenCate (23), and Glaser (10). Only the solutions of l~l ' r and Hobson produced results which were at all satisfactory for the excised crop of the American roach. Secondly, amounts ~ of the chlorides of sodium, potassium, and calcium were varied, and it was found that 14.6 gln. of NaC1, 0.45 gin. of KC1, 0.50 gln. of CaCh, and 0.19 gm. of NaI-ICO8 in 1 liter of water gave the best results among many mixtures tested, when contractions of the cockroach foregut were used as a criterion of adequacy.

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