Objectives Preeclampsia is a pregnancy specific syndrome. Studies have shown that preeclampsia has multiorgan dysfunction effects. This study evaluated biomarkers of renal and liver function among preeclamptic Nigerian women. Study Design This was a cross-sectional study conducted among 49 preeclamptic women and 50 normotensive healthy pregnant women. Method The baseline data comprising age, gestational age, and blood pressure were obtained. Venous blood and spot urine samples were collected from each participant. Plasma obtained from blood samples taken into lithium heparinized vacutainer bottles was assayed for electrolytes, urea, creatinine, total protein, albumin, and uric acid, while sera samples from blood samples taken into serum separation tube- (SST-) gel vacutainer were assayed for aspartate transaminase and alanine transaminase using ion selective electrode technique and Cobas autoanalyzer. Spot urine samples were assayed for protein and creatinine using Pyrogallol's reagent and Jaffe's methods, respectively. Microalbuminuria (protein/creatinine ratio) was generated from spot urine protein and creatinine data. Result The plasma sodium, total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in microalbuminuria, plasma potassium, urea, creatinine, uric acid levels, serum AST, and ALT activities in preeclamptic group. A positive association (p<0.05) between alanine aminotransferase and biomarkers of renal function was observed. Conclusion Preeclampsia has deleterious effects on renal and liver function as shown by alteration of these parameters.
BackgroundFootball sporting exercise is one of the most popular events in the world. While there are well-documented reports on the effects of different athletic sporting activities on the biochemical markers of renal and liver functions, there are paucity of well-documented reports on the effects of football activity on Nigerian sportsmen, hence the need for this study.MethodBiochemical markers of renal and liver functions (urea, creatinine, aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP)) were determined using Cobas c 111 auto-analyser by Roche.ResultsThe mean urea (mmol/L)±SEM, creatinine (μmol/L)±SEM, AST (U/L)±SEM, ALT (U/L)±SEM and ALP (U/L)±SEM values before and after soccer exercise were 3.56±0.12, 3.76±0.13, p=0.000; 79.36±1.53, 95.90±2.03, p=0.000; 32.54±1.15, 35.81±1.32, p=0.000; 15.68±1.02, 13.97±0.81, p=0.000; and 82.21±3.67, 86.08±3.86, p=0.046, respectively. Pearson’s degree of association for AST and ALT before and after exercise were r=0.678, p=0.000 and r=0.770, p=0.000, respectively; ALT and ALP before exercise showed a positive and significant association (r=0.317, p=0.028). On the other hand, there was a negative but insignificant correlation between urea before exercise and ALP after exercise (r=−0.003, p=0.982) and urea before exercise versus AST after exercise (r=−0.120, p=0.418). A positive but insignificant association was observed between urea and creatinine before exercise (r=0.093, p=0.530).ConclusionFootball sporting event is associated with an increase in urea, creatinine, AST and ALP plasma values, and such interpretation of these parameters among sportsmen should be done with caution.
BackgroundPreeclampsia is a multifaceted pregnancy-related disorder affecting women and fetuses. A link between preeclampsia, oxidative stress, and inflammation has been suggested. This study evaluated the interrelationship between biomarkers of oxidative stress, inflammation, and hematological parameters among preeclamptic Nigerian women.Material/MethodsA cross-sectional study was conducted among 49 preeclamptic and 50 normotensive healthy pregnant women. Blood samples were obtained after 20-week gestation in all participants. Levels of superoxide dismutase (SOD), catalase, glutathione (GSH), malonaldehyde (MDA), total protein, high-sensitivity C-reactive protein (hs-CRP), and cardiac-specific troponin I (cTnI) were determined by spectrophotometric and ELISA techniques. FBC, prothrombin time, and activated partial thromboplastin time were determined using an auto-analyzer, Quick’s one-stage, and Proctor’s and Rappaport’s modification methods, respectively.ResultsThe mean SOD (0.051±0.050 vs. 0.073±0.047, p 0.029), catalase (2.62±1.93 vs. 8.48±4.40, p<0.001), GSH (49.05±17.57 vs. 187.10±56.07 p<0.001), platelet (127.63±89.75 vs. 267.16±212.82, p<0.001 were lower in preeclampsia. MDA (7.16±5.00 vs. 2.91±2.66, p<0.001), cTnI (0.46±0.31 vs. 0.13±0.14 p<0.001), PT (19.36±4.06 vs. 13.45±1.97 p<0.001), APTT (45.53±2.92 vs. 37.49±4.99; p<0.001) were higher in preeclampsia. Negative associations between SOD and MDA (r –0.527 p<0.001), CAT and MDA (r –0.469, p 0.001) and positive associations between catalase and hs-CRP (r 0.844, p 0.029), RBC and HB (r 0.442, p 0.001), platelet, and SOD (r 0.353, p 0.013) were observed among preeclamptic volunteers.ConclusionsPreeclampsia is associated with oxidative stress, derangement of hematological and coagulation homeostasis, as well as deleterious effects on the cardiovascular system.
Background: Diabetes mellitus is a chronic and progressive endocrine disorder that may result in macro and microvascular complications. Objective: This study assessed some biochemical analytes in Nigerians who were recently (≤ 6 months) diagnosed with Type 2 diabetes mellitus (T2DM). Methods: 160 T2DM and 90 non-diabetic control participated in this study. Blood samples were collected and analyzed for Heart-type fatty acid-binding protein (HFABP), high sensitivity C-reactive protein (hs-CRP), electrolytes, lipid and renal profile parameters, glycated haemoglobin (HBA1C) and fasting blood glucose (FBG), using standard guidelines. Result: The body mass index (BMI) of the T2DM volunteers was higher than control (P <0.001). The lipid profile, potassium, glucose, HBA1C, urea and creatinine values were elevated (P <0.001) while estimated glomerular filtration rate (eGFR) was lower (P<0.05) in diabetes. The median HFABP and hs-CRP were raised (P <0.05) in T2DM. Positive associations existed between FBG and urea (P <0.001), Creatinine and HBAIC (P <0.001). A logistic regression analysis, shows that an increased BMI, HBA1C, FBG, Cholesterol, urea and creatinine were associated with higher odds (p<0.001) of cardiovascular and renal complications. Conclusion: Elevated hs-CRP, glycated haemoglobin, urea and creatinine among T2DM increase the odds of cardiovascular and renal insults in this population. Keywords: Type 2 diabetes mellitus; renal disease; glycated haemoglobin; high sensitivity C-reactive protein.
It could be concluded that hypothyroidism, hypercholesterolemia, oxidative stress and deranged inflammatory responses are possible features of pre-eclampsia.
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