Objectives: Adropin is a novel marker of metabolic syndrome and insulin resistance. The aim of this study was to explore the association of serum adropin levels with hepatosteatosis among adult patients. Materials and Methods: Serum biochemical parameters including liver and renal function tests, insulin levels, and serum adropin levels were compared between adult patients with nonalcoholic fatty liver disease (NAFLD) and healthy control cases. Results: A total of 51 patients with a mean age of 37.9 ± 9.96 years diagnosed with grade 2–3 hepatosteatosis and 30 healthy control cases with a mean age of 34.8 ± 9.5 years were included in the study. Serum adropin levels in the NAFLD group were statistically significantly lower than in the control cases (588.4 ± 261.0 vs. 894.2 ± 301.2, respectively; p < 0.001). The study participants were further subdivided into 2 groups as patients with (n = 35) or without (n = 46) insulin resistance using the serum homeostatic model of assessment-insulin resistance (HOMA-IR). Serum adropin levels were statistically significantly lower in patients with insulin resistance (p < 0.01). There was a negative correlation between adropin levels and serum insulin, HOMA-IR, urea, gamma-glutamyl transferase, total cholesterol, and triglyceride levels. Conclusion: We observed a decrease in serum adropin levels among adult patients with NAFLD. We also found lower levels of serum adropin in patients with insulin resistance, supporting previous data in the literature. Studies investigating the association of adropin levels with other inflammatory parameters are warranted to define its exact role in the pathogenesis of hepatosteatosis.

The tendency to an increase in omentin-1 levels in postmenopausal women with osteoporosis may be due to a physiologic compensation against bone loss after menopause. The linear relationship between omentin-1 and vitamin D suggests that adipose tissue is one of the target tissues for the vitamin D effect.

No abstract

No abstract

ÖzAmaç: Helikobakter pilori pozitifliği, ülkemizde ve dünyada yüksek prevalansa sahip olup kronik gastrit, peptik ülser, mukoza ile ilişkili lenfoid doku lenfoması ve gastrik adenokarsinomla ilişkili bulunmuştur. Helikobakter pilori pozitifliği, yaygın olarak görülmesi ve geniş bir patolojik spektrumu olması nedeniyle halk sağlığı açısından önemlidir. Çalışmamızda nötrofil lenfosit oranı ve ortalama trombosit hacmi ile helikobakter pilori pozitifliği arasındaki ilişkiyi göstermeyi amaçladık. Yöntemler: Çalışmaya dispeptik şikâyetleri olan hastalardan dışkıda HP direkt antijen testi sonucuna göre HP pozitifliği saptanan 73 olgu ve helikobakter pilori negatif olan 77 olgu çalışmaya alındı. Olgular helikobakter pilori pozitif ve negatif olarak iki gruba ayrıldı. Gruplar arasında laboratuvar parametreleri karşılaştırıldı. Bulgular: Helikobakter pilori pozitif ve helikobakter pilori negatif hasta grupları arasında yaş ortalaması ve cinsiyet arasında anlamlı farklılık yoktu (sırasıyla p=0,26, p=0.621). Helikobakter pilori enfeksiyonu tespit edilen hastalarda kandaki nötrofil sayısında artma (p=0,001) ve lenfosit sayısında azalma (p=0,006) ile birlikte nötrofil lenfosit oranındaki belirgin artış istatistiksel olarak anlamlıydı (p=0,001). Helikobakter pilori negatif hasta grubuna göre helikobakter pilori pozitif hastalarda C-reaktif protein düzeyleri anlamlı olarak yüksek (p=0,011) ve negatif akut faz reaktanı olarak bilinen albümin anlamlı derecede düşüktü (p=0,014). Eritrosit sedimantasyon hızı ve ferritin düzeyleri helikobakter pilori pozitif hasta grubunda daha yüksekti ancak iki grup arasında istatistiksel olarak anlamlı fark yoktu. Her iki grup arasında ortalama trombosit hacmi düzeyleri yönünden anlamlı fark bulunamadı (p=0,477). Sonuç: Çalışmamızda helikobakter pilori pozitif hastalarda ortalama trombosit hacimlerinde anlamlı bir farklılık görülmezken bu hastalarda artmış nötrofil lenfosit oranı tespit ettik. Dispeptik yakınmalarla gelen hastalarda yüksek nötrofil lenfosit oranı helikobakter pilori pozitifliği için bir belirteç olabilir.

Aim: Galectin-3 affects inflammation, cell adhesion, proliferation, differentiation and angiogenesis. Upon examining the pathogenesis of obesity and functions of galectin-3, we thought that galectin-3 may play a significant role in obese patients. This study aims to evaluate the relationship between obesity, insulin resistance and galectin-3 levels. Methods: Eighty five patients aged between 18-50 years were included in this cross-sectional study. BMI>30 were considered obese, those between 25-30 and 18-25 were considered overweight and normal weight, respectively. Patients with HOMA-IR>2.5 were considered insulin-resistant, and those with <2.5 were evaluated as insulin non-resistant.Galectin-3 levels were measured by Enzyme-linked immunosorbent assay. Results: Serum galectin-3 levels were significantly higher in obese patients, but not statistically significantly different between those with and without insulin resistance. Galectin-3 levels were also significantly correlated with BMI and total cholesterol levels, but not correlated with HOMA-IR. Conclusion: In obesity, serum galectin-3 levels may increase to compensate for the inflammation. Our results make it difficult to establish a relationship between insulin resistance and galectin-3.

No abstract

No abstract