Evaluation of the Relation Between Omentin-1 and Vitamin D in Postmenopausal Women With or Without Osteoporosis

Dikker, Okan; Bekpınar, Seldağ; Özdemirler, Gül; Uysal, Müjdat; Vardar, Müberra; Atar, Sevgi; Usta, Murat; Hüner, Berrin

doi:10.1055/s-0043-120110

Cited by 14 publications

(14 citation statements)

References 26 publications

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“…Therefore, both our hereby presented findings and the results of previous studies seem to suggest that there may be a potential mechanistic association between higher circulating omentin-1 and the development of diabetic osteoporosis, and circulating omentin-1 may be upregulated to compensate for bone remodeling enhancement in response to lower BMD caused by cardiometabolic risk factors, inflammation, or vascular damage in T2DM patients. This hypothesis is supported by the report of Dikker et al, which found that omentin-1 levels were significantly increased in postmenopausal women with osteoporosis compared with premenopausal women, and omentin-1 levels positively correlated with vitamin D [ 8 ]. Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment.…”

Section: Discussionsupporting

confidence: 57%

“…Several studies showed that high omentin-1 protected from bone mass loss and osteoporosis by suppressing bone resorption and promoting bone formation in mice and in multiple sclerosis patients [ 15 , 16 ]. Other studies showed that omentin-1 has a negative effect on bone mass at different skeletal sites, and on bone turnover markers through inhibiting bone formation in Chinese premenopausal women, Iranian postmenopausal women, girls with anorexia nervosa, and older men; other studies showed that omentin-1 has no effect in both postmenopausal and premenopausal women and in Chinese healthy males [ 4 , 8 , 14 , 17 , 18 , 19 , 20 ]. Based upon the evidences outlined above, omentin-1 may exert ambiguous effects on bone mass, which may be caused by the small sample sizes, different study populations and metabolic characteristics, and complex regulatory mechanisms in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population

Yan

Zhang

et al. 2020

Mediators of Inflammation

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Aims. Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying the association between circulating omentin-1, bone mineral density (BMD), prior fragility fractures, and other bone metabolic-related parameters. Methods. Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes mellitus (T2DM), and participants were divided into the normal BMD group ( n = 52 ), the osteopenia group ( n = 66 ), and the osteoporosis group ( n = 54 ). The relationship between circulating omentin-1 and diabetic osteoporosis and other parameters was analyzed. Results. Circulating omentin-1 was significantly higher in the osteoporosis group than in the normal group and in the osteopenia group (both P < 0.05 ). Circulating omentin-1 levels were correlated significantly and positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; they were correlated negatively with diastolic blood pressure, triglyceride, hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites, and corresponding T scores, irrespective of age, sex, and body mass index ( P < 0.01 or P < 0.05 ). Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence interval: 1.003-1.139; P < 0.05 ). Lastly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; specificity: 58.5%) in female subjects. Conclusions. High levels of circulating omentin-1 may be associated with the development of osteoporosis in female diabetic subjects and may be a potential biomarker for diabetic osteoporosis in women.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population

Yan

Zhang

et al. 2020

Mediators of Inflammation

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“…Vitamin D could increase serum omentin in participant with lower serum 25(OH) D levels. Cross-sectional studies indicated that women with normal vitamin D levels had significantly higher omentin levels (Dikker et al, 2017), while another study did not show association between vitamin D and omentin in gestational diabetes (Mousa et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D could increase serum omentin in participant with lower serum 25(OH)D levels. Cross‐ sectional studies indicated that women with normal vitamin D levels had significantly higher omentin levels (Dikker et al, ), while another study did not show association between vitamin D and omentin in gestational diabetes (Mousa et al, ). An intervention showed that fortified yogurt with vitamin D for 12 weeks increased the serum levels of omentin, improved glucose markers (except HbA 1 c) and inflammation in postmenopausal women with type 2 diabetes in comparison with plain yogurt (Jafari et al, ).…”

Section: Discussionmentioning

confidence: 99%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

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“…Furthermore, it has been shown that vitamin D regulates adipocyte apoptosis as well as adipokines gene expression such as adiponectin and omentin-1 [22,30]. Of note, Nrg4 as a good adipocytokine has similar features and functions to adiponectin and omentin-1, and also as a neurotrophic factor exerts neurotrophic and neuroprotective effects [3].…”

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confidence: 99%

Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy

Yan

Miao

et al. 2020

Diabetol Metab Syndr

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Background: Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications. Methods: Circulating Nrg4 levels were measured with an ELISA kit in 164 newly diagnosed type 2 diabetes mellitus (nT2DM) patients. The relationship between circulating Nrg4 and DPN and other parameters was analyzed. Results: Circulating Nrg4 levels were significantly lower in nT2DM patients with DPN than those without, and subjects in the highest quartile of circulating Nrg4 had significantly lower vibration perception threshold (VPT), the prevalence of DPN, the proportion of persons with VPT > 25 V, and significantly higher circulating 25(OH)D (all P < 0.01). Moreover, circulating Nrg4 was positively and independently associated with 25(OH)D, and was negatively with VPT (P < 0.01 or P < 0.05), but showed no associations with the prevalence of peripheral arterial disease, diabetic nephropathy, and diabetic retinopathy (all P > 0.05). Additionally,the prevalence of DPN and risk of DPN development were progressively decreased with increasing circulating Nrg4 quartiles, independently of potential confounding factors. Conclusions: These data demonstrate that decreased levels of circulating Nrg4 might lead to the development of DPN through its close interaction with circulating 25(OH)D not with other diabetic vascular complications. Further prospective studies are needed to identify our findings in these populations.

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Evaluation of the Relation Between Omentin-1 and Vitamin D in Postmenopausal Women With or Without Osteoporosis

Cited by 14 publications

References 26 publications

Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population

Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy

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