The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Abstract

Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

Association of serum Vitamin D and omentin-1 in patients with coronary artery disease.

“…14 Fazelian et al have compared omentin-1 levels and vitamin D, before-and after-treatment, in female patients of type 2 diabetes mellitus. He observed significantly raised omentin-1 levels with high levels of vitamin D. 15 Very few studies have been conducted to assess the relationship between vitamin D and omentin-1, however; literature has given the association between 16 Similarly, Gangloff et al; observed the positive correlation between vitamin D and leptin in young males with central obesity. 17 Mohammad SM et al worked on another adipokine adiponectin in diabetic patients and found high vitamin D levels with high adiponectin values.…”

Does Dietary Intake Impact Omentin Gene Expression and Plasma Concentration? A Systematic Review

“…Jafari et al [38] reported that the intake of vitamin D-fortified low-fat yogurt decreased hs-CRP, and improved inflammation and the omentin plasma concentration, independent of a change in body weight or BMI. Similarly, vitamin D supplementation for 16 weeks decreased hs-CRP while increasing IL-10 and omentin plasma concentration [44]. Omentin acts as an anti-inflammatory factor in patients with diabetic obesity [21], as well as one of the mediators of the antioxidant effect of vitamin D [45].…”

The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family

“…For example, statins were shown to decrease the transcription of the KRT6A gene, and subsequent case reports have reported benefits in patients with pachyonychia congenita caused by KRT6A mutations. Vitamin D has been shown to correlate with SERPINA12 levels, but one study found that vitamin D supplementation (50,000 IU/week) did not improve SERPINA12 levels (Fazelian et al, 2018).…”