The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents

Dikker, Okan; Dağ, Nevin Çetin; Şahin, Mustafa Kürşat; Türkkan, Emine; Dağ, Hüseyi̇n

doi:10.1016/j.cyto.2019.154802

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…Angptl 2 and Angptl 3 are members of angiopoietin family and inflammatory mediators related to fat metabolism, which are involved in regulating lipid metabolism and angiogenesis [ 18 ]. Serum physiological level of Angptl 2 can promote angiogenesis, while excessive Angptl 2 can cause vascular inflammation and atherosclerosis [ 19 ]. The increase of serum Angptl 3 level can hinder the clearance of blood triglyceride, promote platelet aggregation, secrete plasminogen activator inhibitor-1, increase the number of foam cells, induce neovascularization, and accelerate the formation of coronary artery stenosis [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long-Term External Counterpulsation Combined with Exercise Therapy on the Establishment of Collateral Circulation in Patients with Coronary Artery Occlusive Disease

Zhang

Mao

et al. 2022

BioMed Research International

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Objective. By detecting the levels of external counterpulsation combined with exercise therapy on the levels of moesin, angiopoietin-like protein2 (Angptl 2), angiopoietin-like protein (Angptl 3), hypoxia inducible factor-1α (HIF-1α), and RNA-34a (miR-34a) in patients with coronary artery occlusive disease, the effect of external counterpulsation combined with exercise therapy on the establishment of occluded coronary collateral circulation was studied. Methods. A retrospective analysis of 166 patients with coronary heart disease was confirmed by coronary angiography results that at least one coronary artery (anterior descending branch, circumflex branch, and right coronary artery) was completely occluded and was classified into the control group (routine medication) and the treatment group (routine drug therapy plus exercise therapy and external counterpulsation) according to the treatment plan of the patient. The serum levels of moesin, Angptl 2, Angptl 3, and HIF-1α were detected by enzyme-linked immunosorbent assay (ELISA) test. The index of microcirculatory resistance (IMR) and coronary flow reserve (CFR) of the two groups of patients were measured before and after 2 weeks of treatment. The formation of collateral circulation was analyzed according to the Rentrop classification method. Results. After treatment, the IMR levels of the two groups were significantly decreased, and the CFR levels were significantly increased. The decrease of IMR level and the increase of CFR level in the experimental group were better than those in the control group ( P < 0.05 ). There was no significant difference in the positive detection rate of moesin antibody between the two groups, but the OD detection value of the treatment group decreased significantly ( P < 0.05 ). The levels of Angptl 2, Angptl 3, and miR-34a in the treatment group were lower than those in the control group, while the relative expression of HIF-1α was higher than that in the control group. The difference was statistically significant ( P < 0.05 ). External counterpulsation combined with exercise therapy improved the formation rate of collateral circulation ( P < 0.05 ). Conclusions. External counterpulsation combined with exercise therapy can reduce moesin antibody, Angptl 2, Angptl 3, and miR-34a levels increase HIF-1α levels, and promote the establishment of occluded coronary collateral circulation.

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Section: Discussionmentioning

confidence: 99%

The Effect of Long-Term External Counterpulsation Combined with Exercise Therapy on the Establishment of Collateral Circulation in Patients with Coronary Artery Occlusive Disease

Zhang

Mao

et al. 2022

BioMed Research International

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“…To the best of the knowledge of the authors of the current study, only two published papers have dealt with the role of ANGPTL-4 in non-alcoholic steatosis. According to one of the studies, the level of ANGPTL-4 was lower in patients with steatosis than in the control group [22]; in the other study from the same centre, no association between the serum level of ANGPTL-4 and hepatosteatosis in adolescents was demonstrated [23].…”

Section: Discussionmentioning

confidence: 93%

Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2020

Ann Agric Environ Med.

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Introduction. Alcohol consumption causes acute and chronic liver injury. The clinical forms of alcohol liver disease (ALD) include steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) associated with liver cirrhosis. Objective. The aim of the study was to determine the levels of novel markers of fibrogenesis and angiogenesis in patients with alcoholic liver cirrhosis. Serum levels of angiopoietin-like peptide 4 (ANGPTL-4), asialoglycoprotein receptor 1 (ASGP-R1), and S100 calcium-binding protein A8 (S100A8) were assessed. Levels of hyaluronic acid (Hyal) and collagen IV (Coll IV) werealso determined at various stages of alcoholic liver cirrhosis. Materials and method. The study group consisted of 72 patients with alcoholic liver cirrhosis, while the control group included 22 healthy subjects without a history of alcohol abuse. The degree of liver cirrhosis was evaluated according to the Pugh-Child criteria (Pugh-Child score). Based on thse scores, patients were assigned to one of three groups: Pugh-Child (P-Ch) A -21 with stage A, P-Ch B -23 with stage B and P-Ch C -28 with stage C liver cirrhosis. Serum levels of markers were determined using ELISA.Results. The study findings demonstrated higher levels of ANGPTL-4, ASGP-R1, S100A, hyaluronic acid and serum collagen IV in the group of patients with alcoholic liver cirrhosis, compared to the control group. Furthermore, their levels increased with the progression of alcoholic liver cirrhosis. Conclusions. The biomarkers analysed in the study may be useful for diagnosis and prognosis in patients with alcoholic liver cirrhosis.

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“…Furthermore, Dikker et al. discovered that obese adolescents had increased levels of ANGPTL 4, TG, cholesterol, and BMI levels 34 . Therefore, they couldn't find a relationship between ANGPTL 4 and hepatosteatosis.…”

Section: Discussionmentioning

confidence: 99%

The serum levels of angiopoietin‐like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group

Hezarkhani,

Hajighaderi,

Hosseinzadeh

et al. 2023

Endocrino Diabet & Metabol

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IntroductionANGPTLs (Angiopoietin‐like proteins) 3 and 4 play an important role in the development of type 2 diabetes. These glycoproteins affect the modulation of glucose and lipid metabolism. They inhibit lipoprotein lipase (LPL) activity and provoke lipolysis. This study was aimed to investigate the protein levels of ANGPTL3 and 4 in the serum of type 2 diabetic patients with metabolic syndrome in comparison to the type 2 diabetic patients without metabolic syndrome and the control group.MethodsThree groups of individuals were included in this study; Group I: 47 patients with type 2 diabetes and metabolic syndrome; Group II: 25 patients with type 2 diabetes without metabolic syndrome; Group III: 40 non‐diabetic healthy people without metabolic syndrome as a control group. After collection of 5 mL fasting blood samples, serum concentrations of fasting blood sugar (FBS), cholesterol (Chol), triglyceride (TG), HDL‐C (High‐density lipoprotein‐Cholesterol) and LDL‐C (Low‐density lipoprotein‐Cholesterol) were measured by the enzymatic method; blood pressure (BP), height and weight with stadiometers; and ANGPTL3 and 4 by the enzyme‐linked immunosorbent assay (ELISA).ResultsThe serum levels of ANGPTL3 was significantly different among our three groups (p = .000). In patients with type 2 diabetes and metabolic syndrome (Group I), ANGPTL3 and 4 levels were lower than the control group.The serum levels of the parameters evaluated in this study (except HDL‐C) was lower in the group II in comparison with the group I, and this difference was significant for TG, Chol, BP and BMI between these two groups. Also, our results revealed that there was a negative correlation between FBS, TG, Chol, LDL‐C and BMI with ANGPTL3 and 4. While, there was a significant positive correlation between ANGPTL4 and ANGPTL3.ConclusionAltogether, our findings suggest that the decreased levels of ANGPTL3 and 4 may be a causative factor for type 2 diabetes.

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The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents

Cited by 7 publications

References 42 publications

The Effect of Long-Term External Counterpulsation Combined with Exercise Therapy on the Establishment of Collateral Circulation in Patients with Coronary Artery Occlusive Disease

The Effect of Long-Term External Counterpulsation Combined with Exercise Therapy on the Establishment of Collateral Circulation in Patients with Coronary Artery Occlusive Disease

Analysis of novel serum markers of fibrosis and angiogenesis in patients with alcoholic liver cirrhosis

The serum levels of angiopoietin‐like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group

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