Dental surgeries can result in traumatic wounds that provoke major discomfort and have a high risk of infection. In recent years, density research has taken a keen interest in finding answers to this problem by looking at the latest results made in regenerative medicine and adapting them to the specificities of oral tissue. One of the undertaken directions is the study of angiogenesis as an integrative part of oral tissue regeneration. The stimulation of this process is intended to enhance the local availability of stem cells, oxygen levels, nutrient supply, and evacuation of toxic waste. For a successful stimulation of local angiogenesis, two major cellular components must be considered: the stem cells and the vascular endothelial cells. The exosomes are extracellular vesicles, which mediate the communication between two cell types. In regenerative dentistry, the analysis of exosome miRNA content taps into the extended communication between these cell types with the purpose of improving the regenerative potential of oral tissue. This review analyzes the stem cells available for the dentistry, the molecular cargo of their exosomes, and the possible implications these may have for a future therapeutic induction of angiogenesis in the oral wounds.

Angiogenesis is a broad spread term of high interest in regenerative medicine and tissue engineering including the dental field. In the last two decades, researchers worldwide struggled to find the best ways to accelerate healing, stimulate soft, and hard tissue remodeling. Stem cells, growth factors, pathways, signals, receptors, genetics are just a few words that describe this area in medicine. Dental implants, bone and soft tissue regeneration using autologous grafts, or xenografts, allografts, their integration and acceptance rely on their material properties. However, the host response, through its vascularization, plays a significant role. The present paper aims to analyze and organize the latest information about the available dental stem cells, the types of growth factors with pro-angiogenic effect and the possible therapeutic effect of enhanced angiogenesis in regenerative dentistry.

In the following case studies we wish to discuss the necessity of making use of digital technology in the occlusion-oriented dental practice. In the three presented cases, patients underwent complex orthodontic, implant and prosthetic treatment, the aim being to re-establish the functionality of the dento-maxillary apparatus. The patients were evaluated clinically at the completion of the treatment. Subsequently, during the follow-ups (which varied between 2 and 4 years), clinical analysis using articulating paper was carried out and possible signs of relapse were specifically searched for.Occlusal clinical analysis was later on compared with the occlusion recorded using the TRIOS® 3 intraoral scanner (3Shape) and the T-Scan™ Novus™ device (TekScan). Clinical and digitally obtained scanner results were similar. The results yielded by the T-Scan™ Novus™ device were different and they were also relevant for elucidating the cause of the symptomatology.

The purpose of this study was to assess the efficiency of low-level LASER therapy (LLLT) in the treatment of temporomandibular joint (TMJ) pain. LLLT therapy was compared with placebo treatment. Material and methods: A number of 20 patients with TMJ pain were included in this study. The diagnosis was done according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). The patients were divided into two groups. The first group received LLLT (660 nm, 90 mW; LaserHF Surgical Unit, Hager & Werken GmbH & Co.KG, Duisburg, Germany) and the second group placebo therapy. TMJ pain was evaluated at baseline and weeks 1 and 2 after therapy. Results: The pain scores decreased for both groups at the 1week point. At the 2-week point there was a significantly decrease in pain scores for LLLT group compared with the placebo group. Still, according to the Mann-Whitney test, there was no statistically significant difference between the placebo group and the LLLT group. Conclusion: Considering these results and the fact that there is no side effect or disadvantage of LLLT, we recommend its use for pain reduction in TMD patients, but with the condition of daily sessions. Further studies are recommended with a larger sample size of patients in order to demonstrate the benefit of LLLT treatment also from a statistical point of view.

(1) Background: Several studies investigating the clinical outcomes of potentially premalignant oral epithelial lesions treated with CO2 lasers have been published over the last decades. (2) Methods: A systematic research review was performed for studies published between 2011 and 2021 in the PubMed, Science Direct, and Google Scholar databases. (3) Results: Initially, the search identified 52 relevant articles. The primary analysis of the titles and abstracts eliminated 22 articles, leaving 30 articles whose full texts were examined. A total of 22 articles met the inclusion criteria. The studies were classified into 3 categories. (4) Conclusions: After evaluating the results of all the studies included in this review, an initial general statement can be made, namely that CO2 lasers are a treatment option worth taking into consideration when approaching oral mucosal lesions. When compared to other types of lasers used in dental practice, the CO2 laser stands out due to its many advantages.