Introduction. The circadian variation of ischemic stroke onset is known, but its impact on recovery prognosis has been less studied. Materials and method. The study included 32 patients with ischemic stroke, admitted to Neurology Departments I and II of the Rehabilitation Hospital in Cluj-Napoca between 1 June 2008 and 31 December 2009 and followed up for 2 years, during 5 successive admissions. The diagnosis of ischemic stroke was defined according to updated World Health Organization criteria. The onset time of ischemic stroke was assigned to one of the following six-hour intervals

The aim of this study was to investigate by transmission electron microscopy the changes occurring in rat hepatocytes following administration of ethyl alcohol for 70 days, as well as to evaluate the effect of mineral water from spring 3 in Baile Tusnad balneoclimatic resort administered for 30 days after completion of ethyl alcohol administration. After 70 days of ethyl alcohol administration, lipid loading in hepatocytes and a reduction of the rough endoplasmic reticulum were observed. The smooth endoplasmic reticulum was found to be much more abundant and in some hepatocytes that contained high lipid amounts, mitochondria had rarefied matrix and cristae. At 30 days from completion of ethyl alcohol administration, the rats that drank tap water showed progressively decreasing lipid loading. Also, the smooth endoplasmic reticulum was less abundant, while the rough endoplasmic reticulum was more abundant than on day 70 of the experiment. The rats that drank mineral water from spring 3 compared to those that drank tap water over the last 30 days of the experiment had lower hepatocyte lipid loading and the rough endoplasmic reticulum was much more abundant. These ultrastructural differences in the degree of lipid loading and the ratio between the smooth and rough endoplasmic reticulum are due to the beneficial effect of mineral water from spring 3 in Baile Tusnad.

Chronic kidney disease (CKD) is one of the most frequently seen comorbidities in patients suffering from musculoskeletal conditions; it is defined by a glomerular filtration rate (GFR) under 60 ml/min/1.73 m2. The following paper focuses on providing a dosage adjustment guideline depending on how advanced renal impairment is. A literature search was carried out using the following items: pharmacokinetics, side effects, drug interactions and dosage, pain medication and antirheumatic drugs in renal failure. The use of non-steroidal anti-inflammatory drugs is inadvisable for a GFR < 30 ml/min as they all pose the risk of inducing acute renal damage, as well as worsening of the underlying chronic renal disease. Non-steroidal antiinflammatory drugs (NSAIDs) should be avoided due to the possibility of kidney disease progression. Paracetamol is an analgesic often chosen in this category of patients. As far as opioid analgesics are concerned, methadone is the only one that can be used without dosage adjustment. Physiotherapy remains a good and safe option for treatment in patients with musculoskeletal complaints. The use of analgesics in patients with CKD continues to be a challenge, as more research is needed.

Introduction Recent statistics show an increase in the prevalence of the elderly population. The year 2012 was declared European Year for Active Ageing and Solidarity between Generations, and the European Commission launched campaigns like The Active and Assisted Living Joint Program (AAL JP). Rehabilitation in the elderly is a desideratum, but the problems of rehabilitation in the elderly are numerous. The aim of the study was to evaluate degree of acceptance/implementation of different technologies in Romania, of monitoring in the rehabilitation activity conducted at home. Material and methods the study comprised 154 persons with a mean age of 73.37 ± 7.33 years, of which 64 (41.6%) male and 90 (58.4%) female. All subjects completed a questionnaire regarding the living conditions and health status, about the degree of acceptance of intelligent technologies for monitoring current health status/reporting acute events. Results 18.2% used the Internet frequently, and the rest used it almost never or rarely. 71.9 % of patients agreed to wear a portable sensor (p=0.07 between men and women), 33.1% accepted videocam, 47.4% accepted a screen, 41.3% accepted living room monitoring, 68% sensor in the room on the wall and 69.1% accepted fall detection sensor. No significant differences were found regarding the acceptance vs rejection of personal sensors, living room monitoring, sensors in the room, fall detection sensors depending on the gender, income level, type of caregiving. Using of videocam and screen was influenced by type of care giving and income (p=0.002, p<0.001, respectively for screen p=0.032 and p=0.003). In conclusion, Romanian old people are not keen on using intelligent devices for health status related to acute event monitoring. More programs and measures are needed for device implementation in real life.

Heart failure is a significant healthcare problem, because of its impact at the individual and populational level, through multiple rehospitalizations and increased morbi-mortality. At the individual level, the multidimensional impact of this clinical condition and its treatment on patients' daily lives is reflected in the quality of life (QoL). QoL needs to be accurately measured, because it's related to high hospitalization and mortality rates and provides valuable information that cannot be directly obtained using clinical, biological or imaging measurements. For these reasons, QoL evaluation (global score, subscale scores, answers to various items, etc.) is a significant parameter for assessing the impact of and for structuring the cardiac rehabilitation programs (exercise training, nutritional counseling, psychosocial support and interventions, etc). In order to increase the long-term efficiency, these programs need also to include strategies to optimize and increase adherence to lifestyle changes and to medical therapy.