Cytokine-hormonal interrelations at 291 boys aged 14–17 adjusted to level of puberty and the thyroid gland condition were analyzed. It was shown that the formation of cytokine-hormonal relationships depends on of the both on presences of thyroid pathologies and on degree of puberty. The role of cytokines increased at boys both with thyroid pathology and the sex delay development. Existence of close connections between thyroid, sex hormones, insulin-like growth factor, sex hormonebinding globulin, melatonin and cytokines (IL-1β, TNF-α, IL-6, IL-10) also was established. The character and the structure of interactions reflected the differences in formation of mechanisms of the sex delay development against the thyroid gland pathology.
The study of cytokine profile in teenage boys from 14 to 17 years with delayed puberty madeit possible to establish an increased interlekin1β concentration together with simultaneous decreasein TNF α concentration. Interlekin 1β and TNF α combined impact on the FSH production wasestablished. There were revealed correlations between the levels of sexual and gonadotropic hormonesand cytokines which suggested cytokines participation in the pituitary-gonadal system functioning.
Melatonin production in healthy teens aged 10–16 years and their peers with diffuse non-toxic goiter. On the basis of mathematical analysis of its interaction with thyroid and sexual hormones, thyrotropin, prolactin and type 1 insulin-like growth factor participation of melatonin in the regulation of the hormone-producing function of the thyroid gland, the nature of which depends on the stage of puberty and adolescence.
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