Formation of Cytokine-Hormonal Interactions at Boys With Diffuse Nontoxic Goiter With Physiological and Pathological Puberty

Abstract

Cytokine-hormonal interrelations at 291 boys aged 14–17 adjusted to level of puberty and the thyroid gland condition were analyzed. It was shown that the formation of cytokine-hormonal relationships depends on of the both on presences of thyroid pathologies and on degree of puberty. The role of cytokines increased at boys both with thyroid pathology and the sex delay development. Existence of close connections between thyroid, sex hormones, insulin-like growth factor, sex hormonebinding globulin, melatonin and cytokines (IL-1β, TNF-α, IL-6, IL-10) also was established. The character and the structure of interactions reflected the differences in formation of mechanisms of the sex delay development against the thyroid gland pathology.