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ABSTRACT:The effect of molecular weight of polyethyleneglycol (PEG) and sodium chloride (NaCl) on the gelation temperature of methylcellulose (MC) was studied with the objective to develop a MC based formulation for sustained delivery of ophthalmic drug. The gelation temperature of 1% MC was 60 6 0.40 C. It was found that the gelation temperature of MC was reduced with the addition of 10% PEG and extent of reduction of gelation temperature was depended on the molecular weight of PEG at same PEG concentration of 10%. The gelation temperature of MC was reduced by 10.4 to 5.9 C with the increasing molecular weight of PEG starting from 400 to 20,000 (Mn) depending on the method of determination of gelation temperature. To reduce the gelation temperature of MC close to physiological temperature (37 C), 6% NaCl was added in the different MC-PEG combinations containing different molecular weight of PEG. It was observed that the drug release time increased from 5 to 8 h with the increase in molecular weight of PEG from 400 to 20,000 (Mn) and this was due to the maximum viscosity and gel strength of MC-PEG20000-NaCl ternary combination.

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The impedance, capacitance and conductance of deionized water-glucose polar solution is measured by employing impedance spectroscopy and a quasi-oscillatory nature of variation with glucose content in the solution is observed. Such quasi-oscillatory nature is attributed to the randomly distributed water-water, water-glucose and glucose-glucose dipole interactions at the molecular level in the solution. A relevant analytical model is developed on the basis of such random distribution of the molecular dipoles and the experimental data agree well with those obtained from the theoretical model. The electrical parameters are measured in the frequency range of 100Hz to 4MHz for the volume fractions of glucose with respect to water in the range of 0.1 to 0.5. The impedance, capacitance and conductance are obtained to be in the range of 1.03 kΩ – 112 kΩ, 34.9 pF – 1.66 nF, and 8.95 μS – 52.9 μS respectively for the glucose volume fraction range considered.

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