Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients

Singh, Bisu; Bera, Nirmal Kumar; Nayak, Chittaranjan; Chaudhuri, Tapas Kumar

doi:10.1016/j.cyto.2009.05.005

Cited by 46 publications

(19 citation statements)

References 54 publications

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“…A marginally statistically association between the severity of negative symptoms and a polymorphism of the IL6 gene (IL6-1 rs1800797) has also been described in schizophrenia (Liu et al, 2010). Some (Akiyama, 1999; Fernandez-Egea et al, 2009; Ganguli et al, 1994) but not all studies (Singh et al, 2009) have found an increased IL6 in drug-naïve patients. The described abnormality in each of these markers provides a degree of validation of the abnormality in the other.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features

García-Rizo

Fernández-Egea

Oliveira

et al. 2012

Psychiatry Research

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Newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis appear to have increases in pro-inflammatory cytokines. Patients characterized by primary, enduring negative symptoms (deficit symptoms) differ from patients without such features with regard to course of illness, treatment response, risk factors and metabolic disturbances. We hypothesized that they would also differ on the inflammatory markers, interleukin-6 (IL6) and C-reactive protein (CRP) concentrations. Newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis were categorized into deficit (N=20) and nondeficit (N=42) groups, and were matched on age, gender, body mass index, smoking, cortisol level, socioeconomic status, and the severity of psychotic symptoms. Fasting concentrations of IL6 levels were significantly higher in deficit (mean [SD]) (8.0 pg/ml [12.7]) than nondeficit patients (0.3 pg/ml [1.3]) CRP levels were also significantly higher in the deficit patients (0.3 mg/dl [0.4]) vs. (0.2 mg/dl [0.4]), respectively. In contrast, 2-h glucose concentrations (2HG) in a glucose tolerance test were lower in the deficit than the nondeficit group. Our results show a double dissociation with regard to glucose intolerance and inflammation: the deficit group has greater inflammation, but less severe glucose intolerance. These results provide further evidence for the validity of the deficit/nondeficit categorization.

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Section: Discussionmentioning

confidence: 99%

Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features

García-Rizo

Fernández-Egea

Oliveira

et al. 2012

Psychiatry Research

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“…Possible role of the immune response system in the pathogenesis of schizophrenia is indicated by several authors (Plata-Salaman and Turrin 1999;Liu et al 2010;Singh et al 2009). …”

Section: Discussionmentioning

confidence: 96%

Functional Polymorphism in the Interleukin-6 and Interleukin-10 Genes in Patients with Paranoid Schizophrenia —A Case-Control Study

et al. 2010

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Schizophrenia is a multifactorial disease with changes in immunological system. Such changes are the result of cytokine-level disturbances connected with cytokine gene polymorphisms. However, research about cytokine gene polymorphisms in schizophrenia has been surprisingly limited and ambiguous. The aim of the study was to identify whether polymorphisms of interleukin (IL)-6 and IL-10 are risk factors for the development of paranoid schizophrenia in case-control study. IL-6 (-174G/C; rs 1800795) and IL-10 (-1082G/A; rs 1800896) promoter polymorphisms in patients with paranoid schizophrenia and healthy individuals were genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Differences in IL-6 and IL-10 promoter haplotypes may play an important role in determining the transcription level for IL-6 and IL-10 genes in schizophrenic patients. The presence of allele C at position -174 of IL-6 promoter sequence may correlate with increasing risk of paranoid schizophrenia in the Polish population, but research on a broadened group of people is needed. The presence of allele G at position -1082 of IL-10 promoter sequence correlates with increasing risk of paranoid schizophrenia in the Polish population. The coexistence of genotype GG at position -1082 of IL-10 promoter sequence and genotype GC at position -174 of IL-6 promoter sequence correlates with increasing risk of paranoid schizophrenia in the Polish population.

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“…Many authors have observed the lack of consistent results regarding cytokines in schizophrenia (Potvin et al, 2008;Miller et al, 2011;Na et al, 2014). For example, although there is evidence of increased IL-2 (Potvin et al, 2008;Miller et al, 2011), IL-6 (Kubistova et al, 2012Al-Asmari and Khan, 2014;DunjicKostic et al, 2013;Kalmady et al, 2014;Sasayama et al, 2013;Song et al, 2014), and IL-8 (Maes et al, 2002;Brown et al, 2004;Zhang et al, 2004) levels in schizophrenia, some studies have not found a significant difference from healthy controls in IL-2 (Na et al, 2014), IL-6 (Baker et al, 1996), andIL-8 (O'Brien et al, 2008;Kubistova et al, 2012), or even a decrease in IL-2 (Miller et al, 2011;Na et al, 2014) and IL-6 levels compared to controls (Singh et al, 2009). The decrease in the TNF-a level in schizophrenia patients in this study is consistent with a recent study (Francesconi et al, 2011), although previous studies have observed significantly greater TNF-a levels (O'Brien et al, 2008;Kim et al, 2009), or no difference from healthy controls (Borovcanin et al, 2012(Borovcanin et al, , 2013.…”

Section: Decreased Bdnf and Altered Cytokines In Schizophreniamentioning

confidence: 93%

Interaction of BDNF with cytokines in chronic schizophrenia

Zhang

Tan

Chen

et al. 2016

Brain, Behavior, and Immunity

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Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients

Cited by 46 publications

References 54 publications

Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features

Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features

Functional Polymorphism in the Interleukin-6 and Interleukin-10 Genes in Patients with Paranoid Schizophrenia —A Case-Control Study

Interaction of BDNF with cytokines in chronic schizophrenia

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