Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD.
HOTAIR
is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the
HOTAIR
in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of
HOTAIR
lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of
HOTAIR
is up-regulated in blood samples of patients with CAD.
Recent studies have shown that up to 90% of the genomic DNA are transcribed to a complicated network of transcripts. The major transcripts which are over 200 nt in length includes Long Non-coding RNAs (LncRNA) (Ponting et al., 2009). Also, it has been revealed that lncRNAs, as the major regulators of gene transcriptional system, are involved in the different biological process such as cell cycle regulation and cytoplasmic transport (Wang et al., 2011).Much investigations have been focused on characterizing the role of lncRNAs in the prognosis of CRC (
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