SNHG1 Long Noncoding RNA is Potentially Up-Regulated in Colorectal Adenocarcinoma

Abstract

Recent studies have shown that up to 90% of the genomic DNA are transcribed to a complicated network of transcripts. The major transcripts which are over 200 nt in length includes Long Non-coding RNAs (LncRNA) (Ponting et al., 2009). Also, it has been revealed that lncRNAs, as the major regulators of gene transcriptional system, are involved in the different biological process such as cell cycle regulation and cytoplasmic transport (Wang et al., 2011).Much investigations have been focused on characterizing the role of lncRNAs in the prognosis of CRC (

Long noncoding RNA small nucleolar RNA host gene 1 as a potential novel biomarker for intraperitoneal free cancer cells in colorectal cancer

“…Based on reported studies of SNHG1 and CRC, 39 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 the pretest probability of the sensitivity of SNHG1 testing was set at 0.6 to 0.9, and the pretest probability of specificity was set at 0.714 to 0.9. On the basis of reported studies of CEA mRNA and CRC, 13 , 14 , 18 , 24 , 25 , 26 , 27 , 28 the pretest probability of the sensitivity of CEA testing was set at 0.33 to 0.667, and the pretest probability of specificity was set at 0.697 to 0.864.Based on the reported studies of IFCCs and CRC, 13 , 14 , 18 , 20 , 21 , 24 , 25 , 26 , 27 , 28 the pretest probability of positive rate sensitivity was set at 0.08 to 0.379.…”

Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer

“…SNHGs, termed as lncRNA small nucleolar RNA host genes, have been reported to be abnormally expressed in various cancers and can act as a reliable prognosis factor [30]. SNHG1 has been exhibited to be upregulated in colorectal cancer and hepatocellular carcinoma, and leads to poor prognosis [31,32]; SNHG6 was reported to be overexpressed in gastric cancer and its level has a positive correlation with unfavorable factors, thus predicted poor prognosis [33]. In the current study, the expression level of SNHG11 was determined in prostate cancer tissues and cells.…”

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

“…Furthermore, SNHG1 has been found to interact with key molecules such as MYC and SLC3A2, thereby modulating gene expression and the PI3K/AKT pathway. These findings underscore SNHG1′s potential as a crucial mediator of immune responses, inflammation, and tumor–stroma crosstalk via extracellular vesicles/exosomes in CRC [ 127 , 128 , 129 ].…”