HOTAIR: A Promising Long Non-coding RNA with Potential Role in Breast Invasive Carcinoma

Avazpour, Niloofar; Hajjari, Mohammadreza; Birgani, Maryam Tahmasebi

doi:10.3389/fgene.2017.00170

Cited by 23 publications

(21 citation statements)

References 16 publications

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“…In recent years, many studies have shown that lncRNAs play important roles in gene regulation, transport, differentiation, dosage compensation, and protein synthesis. [8][9][10] The lncRNA SNHG1 is upregulated in many cancers. 7 For example, lncRNA HOX transcript antisense RNA has been verified as an effective diagnostic marker in patients with liver, colon, breast, and pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer

Chen

Dong

Wang

et al. 2018

J of Cellular Biochemistry

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Background Pancreatic cancer (PC) has become the fourth most lethal among human cancers. Long noncoding RNAs (lncRNAs) have been reported to play a role in the progression of a variety of cancers. However, the role of lncRNA SNHG1 in PC is not clear. Methods Real‐time Quantitative PCR Detection System (qPCR) was used to detect the expression of SNHG1 in PC cells. Then, the SNHG1 knockdown cell was constructed with si‐SNHG1. AsPC‐1 and PANC1 cells were used to analyze the ability of cell proliferation, invasion, and migration. MTT assay was used to analyze the proliferation ability. Transwell experiments and wound healing experiments were used to detect the capacity of invasion and migration. Finally, Western blot analysis was used to explore the mechanism of SNHG1 in PC. Results SNHG1 was significantly upregulated in PC cells. Knockdown of SNHG1 could obviously suppress cell proliferation, invasion, and migration. Furthermore, SNHG1 knockdown inhibited the activation of the Notch‐1 signaling pathway and inhibited the expression of N‐cadherin, Hes1, Vimentin, Notch‐1. The inhabitation was reversed when Notch‐1 was overexpressed in si‐SNHG1 cells. Conclusion The lncRNA SNHG1 promotes cell growth and metastasis in PC through activation of the Notch‐1 signaling pathway in PC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer

Chen

Dong

Wang

et al. 2018

J of Cellular Biochemistry

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“…In addition, HOTAIR is overexpressed in HER2positive, estrogen receptor (ER)-negative, and progesterone receptor (PR)-negative patients ( Supplementary Fig. S8B), which is consistent with the previous research (24). To predict the molecular mechanism of HOTAIR in breast cancer, we investigated the coexpression networks of HOTAIR using coexpression function that was implemented in lnCAR.…”

Section: Web Interface and Usagesupporting

confidence: 86%

lnCAR: A Comprehensive Resource for lncRNAs from Cancer Arrays

Zheng

Liu

et al. 2019

Cancer Research

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Long noncoding RNAs (lncRNA) have emerged as promising biomarkers in cancer diagnosis, treatment, and prognosis. Recent studies suggest that a large number of coding gene expression microarray probes could be reannotated as lncRNAs. Microarray, once the most cutting-edge highthroughput gene expression technology, has been used for thousands of cancer studies and has brought invaluable resources for studying the functions of lncRNA in cancer development. However, a comprehensive lncRNA resource based on microarray data is still lacking. Here, we present lnCAR (lncRNAs from cancer arrays), a comprehensive open resource for providing expression profiles and prognostic landscape of lncRNAs derived from reannotation of public microarray data. Currently, lnCAR contains 52,300 samples for differential expression analysis and 12,883 samples for survival analysis from 10 cancer types. lnCAR allows users to interactively explore any annotated or novel lncRNAs. We believe lnCAR will serve as a valuable resource for the community focused on lncRNA research in cancer. Significance: lnCAR, a new interactive tool of reannotated public cancer-related microarray data, provides expression profiles and prognostic landscapes of lncRNAs across thousands of samples and multiple cancer types.

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“…In breast cancer, an expression panel of lncRNAs has been shown to perform as well as the Prediction Analysis of Microarray 50 at classifying breast cancer intrinsic subtypes and predicting overall survival . Furthermore, lncRNAs can function as oncogenes as exemplified by HOTAIR which supports tumor cell invasion, cell proliferation, and metastasis in breast cancer . Despite increasing evidence that lncRNAs are functional molecules, the analysis of the majority of lncRNAs is preliminary and has not resulted in a clear pattern of expression in models of progression …”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

DeVaux

Ropri

Grimm

et al. 2020

J of Cellular Biochemistry

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Ductal carcinoma in situ (DCIS) is a nonobligate precursor to invasive breast cancer. Only a small percentage of DCIS cases are predicted to progress; however, there is no method to determine which DCIS lesions will remain innocuous from those that will become invasive disease. Therefore, DCIS is treated aggressively creating a current state of overdiagnosis and overtreatment. There is a critical need to identify functional determinants of progression of DCIS to invasive ductal carcinoma (IDC). Interrogating biopsies from five patients with contiguous DCIS and IDC lesions, we have shown that expression of the long noncoding RNA BHLHE40-AS1 increases with disease progression.BHLHE40-AS1 expression supports DCIS cell proliferation, motility, and invasive potential. Mechanistically, BHLHE40-AS1 modulates interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3) activity and a proinflammatory cytokine signature, in part through interaction with interleukin enhancer-binding factor 3. These data suggest that BHLHE40-AS1 supports early breast cancer progression by engaging STAT3 signaling, creating an immune-permissive microenvironment.

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HOTAIR: A Promising Long Non-coding RNA with Potential Role in Breast Invasive Carcinoma

Cited by 23 publications

References 16 publications

RETRACTED: Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer

RETRACTED: Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer

lnCAR: A Comprehensive Resource for lncRNAs from Cancer Arrays

Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

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