An ESIPT based fluorescent sensor 1 was developed, which could selectively detect and differentiate trivalent metal ions Cr3+, Al3+ and Fe3+ in aqueous. The cell imaging experiments confirmed that 1 can be used for monitoring intracellular Cr3+ and Al3+ levels in living cells.
The present study was started with aim to develop lamivudine mannose conjugated solid lipid nanoparticles for targeted drug delivery to brain. Mannosylated solid lipid nanoparticles enable improvement of brain bioavailability and reduction of lamivudine toxicity. The lamivudine loaded solid lipid nanoparticles were prepared by solvent injection method. The mannose conjugation on nanoparticles surface was done by reaction between aldehyde group of mannose and free amino function group on nanoparticles surface. The formulation variables were successfully optimized using Box Behnken design. The particle size, entrapment efficiency and zeta potential of optimized formulation were found to be 206.4 nm, 48.12% and-43.6 mV respectively. Nanoparticles showed sustained release profile up to 12 hrs. The mannosylated solid lipid nanoparticles showed low % hemolysis and better uptake inside the macrophages cell as compare to pure drug. Results of this study indicated that mannose conjugated solid lipid nanoparticles would be a promising therapeutic system for efficient delivery of the lamivudine into brain macrophages.
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