Our previous report showed that our current benchmark agent, 4-methoxyphenyl p-toluenesulfonate, is a selective antimalarial/anticancer agent. A series of related sulfones and sulfonic acid esters is now examined. 4-Allyloxyphenyl p-toluenesulfonate is a superior antimalarial/anticancer agent. 4-Methoxyphenyl 4-nitrobenzenesulfonate is a superior antimalarial agent, but shows poorer inhibition of human skin cancer cells.
The use and construction of a novel apparatus for a variant of conventional column chromatography is described. Relative to a single large conventional column, a bundled apparatus facilitates scale-up by accelerating fraction collection. The bundled approach permits prior knowledge of total running time, total solvent volume, and product location.
Thioethers Q 0580 A Gentle and Efficient Route for the Deoxygenation of Sulfoxides Using Catecholborane (HBcat; cat = 1,2-O2C6H4). -The deoxygenation of sulfoxides is investigated under NMR-conditions using catacholborane as the reagent. The time for complete conversion significantly depends on the structure of the substrate. The reactions can be improved by the addition of Rh-catalysts (no details). -(HARRISON, D. J.; TAM, N. C.; VOGELS, C. M.; LANGLER, R. F.; BAKER, R. T.; DECKEN, A.; WESTCOTT*, S. A.; Tetrahedron Lett. 45 (2004) 46, 8493-8496; Dep. Chem., Mount Allison Univ., Sackville, New Brunswick E4L 1G8, Can.; Eng.) -Mais 08-089
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