Epidemiological studies have suggested that there is an association between dietary acid load (DAL) with complications and outcomes of pregnancy. The current study aimed to explore the impact of DAL on theses parameters through a prospective cohort of Iranian pregnant women. In this prospective cohort study, 812 singleton pregnant women without any medical condition, use of medications, and without following a specific diet were included. Dietary intake of participants was examined using a 117-item semiquantitative food-frequency questionnaire (FFQ). Net endogenous acid production (NEAP) and potential renal acid load (PRAL) parameters were used to explore potential DAL using the suggested formula. Multinomial logistic regression analysis was used and odds ratio (OR) and 95% corresponding confidence interval (CI) were reported. DAL (NEAP and PRAL) was not associated with pregnancy outcomes including birth weight, birth height and birth head circumference (all P values > .05). NEAP was associated with preeclampsia (Model 3: OR = 0.48, 95%CI (0.25, 0.94); P trend = 0.05), systolic blood pressure (SBP) (Model 2: OR = 3.99, 95%CI (1.09, 14.53); P trend = 0.04), diastolic blood pressure (DBP) (Model 3: OR = 2.45, 95%CI (1.05, 5.72); P trend = 0.03), and intra-uterine growth restriction (IUGR) (Model 3: OR = 2.82, 95%CI (1.02, 7.78); P trend = 0.01). Moreover, PRAL was related with risk of pre-eclampsia (Model 3: OR = 0.41, 95%CI (0.19, 0.86); P trend = 0.003), SBP (Model 2: OR = 6.07, 95%CI (1.23, 29.94); P trend = 0.03), DBP (Model 3: OR = 3.62, 95% CI (1.23, 10.65); P trend = 0.03), and IUGR (Model 2: OR = 2.63, 95%CI (0.93, 7.44); P trend = 0.02). Our study focused on DAL which showed a significant association with pregnancy-related complications including higher SBP, DBP, IUGR, and pre-eclampsia. Further research with larger sample sizes in different populations might be required to evaluate the compatibility of DAL during pregnancy ARTICLE HISTORY
In this study, we investigated the associations of maternal dietary iron intake during the first trimester of pregnancy and pregnancy outcomes and related complications in pregnant women of Isfahan, Iran. In this prospective study, 812 healthy first-trimester singleton pregnant women were selected randomly from 20 various health centers across Isfahan city during 2015-2016. The maternal dietary iron classified into 2 groups, including heme and non-heme iron. Factors including pre-eclampsia, gestational hypertension, gestational diabetes mellitus, intrauterine growth restriction (IUGR), and nausea and vomiting in pregnancy considered as the pregnancy-related complications. Infant's birth weight, birth height, and birth head circumference were also determined as the pregnancy-outcomes. There was a significant association between total iron consumption and infant head circumference (p = 0.01). Total maternal iron (the sum of heme and non-heme iron) was negatively associated with both infant's birth height (p = 0.006) and birth weight (p = 0.02). Non-heme iron consumption is positively associated with high-risk of IUGR (p = 0.004). Heme intake was associated with an increased risk of maternal fasting blood sugar (FBS) (p = 0.04). Higher heme, non-heme, and total iron intake were associated with lower risk of pre-eclampsia (heme: crude p = 0.05; non-heme iron: adjusted p = 0.02; total iron: adjusted p = 0.05). Maternal total iron intake was directly associated with infant head circumference, whereas, negatively associated with both birth weight and birth height. High non-heme iron intake may increase the risk of IUGR, and a high intake of heme iron may increase FBS.
Abstract. Background: Considering limited data on the association between dietary inflammatory index (DII) and demyelinating autoimmune diseases, here, we studied this issue in the early diagnosed patients [e.g., preceding Multiple Sclerosis (MS) diagnosing level (Clinically Isolated Syndrome (CIS), and Radiologically Isolated Syndrome (RIS), MS, and Neuromyelitis Optica Spectrum Disorder (NMOSD)] using a case-control study among the Iranian population. Methods: A total of 291 subjects were selected as the case (Patients with demyelinating autoimmune diseases including CIS, RIS, MS, and NMOSD, who were diagnosed less than six months before recruitment) and 297 others as control. A 117-item semi-quantitative food frequency questionnaire (FFQ) was obtained from all of the participants and DII was calculated. Results: After controlling for potential confounders, adherence to a pro-inflammatory diet was associated with a higher risk of demyelinating autoimmune diseases (OR=2.05, 95% CI: 0.51, 3.58), EDSS (OR=2.02, 95% CI: 0.51, 3.53), active plaque (OR=1.90, 95% CI: 0.08, 3.71), higher lesion load (OR=2.11, 95% CI: 0.58, 3.64), LETM (OR=2.19, 95% CI: 0.27, 4.11), higher number of plaques (OR=2.11, 95% CI: 0.58, 3.64), and brain atrophy (OR=2.12, 95% CI: 0.57, 3.67). Conclusion: Our study suggests a possible link between the inflammatory potential of the diet and demyelinating autoimmune disease; however, further prospective cohort studies are needed to draw a causal link on this issue.
Background Recent studies suggest that serum vitamin D may be associated with semen parameters. In the present cross-sectional study, we attempted to investigate the association between serum vitamin D levels and semen parameters among Iranian sub-fertile men. Results A total of 350 infertile men recruited for this cross-sectional study using a simple random sampling method with a mean age of 34.77 years old, body mass index of 26.67 kg/m2, serum vitamin D of 20.17 ng/ml, semen volume of 3.82 mL, sperm count of 44.48 (106/mL), sperm total motility of 38.10 %, and morphologically normal sperm of 7.0 %. After controlling for potential confounders, serum vitamin D was positively associated with semen volume (β = 0.63, 95 % CI: 0.06, 1.20), sperm count (β = 14.40, 95 % CI: 4.56, 24.25), sperm total motility (β = 18.12, 95 % CI: 12.37, 23.86), and sperm normal morphology (β = 1.95, 95 % CI: 1.07, 2.83). Conclusions The present findings suggest that higher serum vitamin D levels are positively associated with higher semen volume, sperm count, sperm total motility, and normal morphology rate. These findings, however, do not specify a cause-and-effect relationship, and there is a need for further research in this area to understand whether vitamin D supplementation can improve semen parameters.
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