Association between dietary inflammatory index and risk of demyelinating autoimmune diseases

Hajianfar, Hossein; Mirmossayeb, Omid; Mollaghasemi, Negar; Nejad, Vahid Shaygan; Arab, Arman

doi:10.1024/0300-9831/a000754

Cited by 5 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants with MS had a significantly more pro-inflammatory DII than age- and sex-matched controls. In two recent studies, a higher risk of demyelinating autoimmune diseases, including MS, were linked to eating a pro-inflammatory diet ( 45 , 46 ). In our study, findings among participants with MS confirmed these results; i.e., they had a significantly more pro-inflammatory DII scores than age- and sex-matched controls.…”

Section: Discussionmentioning

confidence: 99%

Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan

Alhaj

Trabelsi

Younes³

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

BackgroundMultiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.PurposeThis study aims to examine the association of the inflammatory capacity of diet measured by DII with MS in Jordan.MethodsThis prevalent case-control study included participants of both sexes, aged between 20 and 60 years. The cases (n = 541) had a confirmed diagnosis of prevalent Multiple Sclerosis (MS) in the previous 3 years, and controls (n = 607) were apparently healthy individuals matched on sex and age (42 ± 4 years). A validated Arabic food frequency questionnaire (FFQ) was utilized to obtain estimated dietary intake. Dietary data from the FFQ were analyzed using ESHA’s Food Processor® nutrition analysis software, and the results were used to calculate the DII scores. Logistic regression analyses, controlling for covariates such as age, sex, body mass index, and smoking status, were used to measure the association between DII score and MS outcomes.ResultsCases represent a mixed sample of MS phenotypes and controls were comparable on age and sex. However, controls tended to be taller, lighter, had a lower BMI, and had a lower smoking rate. After controlling for age, BMI, sex, and smoking status, there was a consistent increase in MS risk according to DII score, with a 10-fold increase in odds in quartile 4 vs. quartile 1 [ORquartile 4vs1 = 10.17 (95% CI: 6.88; 15.04)]. For each point increase in DII score, there was nearly a doubling of odds [OR1 = 1.75 (95% CI: 1.59; 1.92)]. Individual nutrients and food values aligned according to their contribution to the DII score calculations.ConclusionThe findings of this study, obtained in MS patients with varied illness duration over the previous 3 years, are consistent with an association between the overall inflammatory potential of diet and MS odds. Our findings among MS participants showed a significantly more pro-inflammatory DII scores than age- and sex-matched controls. Our results also suggest that MS group had a diet rich in pro-inflammatory foods and nutrients.

show abstract

Section: Discussionmentioning

confidence: 99%

Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan

Alhaj

Trabelsi

Younes³

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…In susceptible individuals, certain foods may increase or decrease the risk of NMOSD 13 , 37 . We found that a higher consumption of oily fish was associated with a lower risk of AQP4-positive NMOSD.…”

Section: Discussionmentioning

confidence: 99%

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Wang¹,

Lin²,

Wu³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory disorders of the central nervous system targeting aquaporin‐4 (AQP4). The risk factors for NMOSD remain to be determined, though they may be related to diet and nutrition. This study aimed to explore the possibility of a causal relationship between specific food intake and AQP4-positive NMOSD risk. The study followed a two-sample Mendelian randomization (MR) design. Genetic instruments and self-reported information on the intake of 29 types of food were obtained from a genome-wide association study (GWAS) on 445,779 UK Biobank participants. A total of 132 individuals with AQP4-positive NMOSD and 784 controls from this GWAS were included in our study. The associations were evaluated using inverse-variance-weighted meta-analysis, weighted-median analysis, and MR-Egger regression. A high consumption of oily fish and raw vegetables was associated with a decreased risk of AQP4-positive NMOSD (odds ratio [OR] = 1.78 × 10−16, 95% confidence interval [CI] = 2.60 × 10−25–1.22 × 10−7, p = 0.001; OR = 5.28 × 10−6, 95% CI = 4.67 × 10−11–0.598, p = 0.041, respectively). The results were consistent in the sensitivity analyses, and no evidence of directional pleiotropy was observed. Our study provides useful implications for the development of AQP4-positive NMOSD prevention strategies. Further research is needed to determine the exact causal relationship and mechanisms underlying the association between specific food intake and AQP4-positive NMOSD.

show abstract

“…Likewise, the Mediterranean diet and other healthy dietary patterns also associated with reduced odds of FDE in case-control studies [121,122] . In contrast, pro-inflammatory diets (based on the dietary inflammation index [123] ) enriched in added sugars and ultra-processed foods are associated with increased FDE odds [124] and increased risk of autoimmune demyelinating diseases [125,126] . Corroborating these findings, a case-control study reported that low intake of fiber, vitamin D, and α-linolenic acid associated with increased odds of FDE [127] .…”

Section: Dietary Impacts On Fdesmentioning

confidence: 99%

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Plafker¹,

Titcomb²,

Zyla-Jackson³

et al. 2023

Immunometabolism

View full text Add to dashboard Cite

This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.

show abstract

Association between dietary inflammatory index and risk of demyelinating autoimmune diseases

Cited by 5 publications

References 38 publications

Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan

Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Contact Info

Product

Resources

About