Is there a relationship between serum vitamin D and semen parameters? A cross-sectional sample of the Iranian infertile men

Hajianfar, Hossein; Karimi, Elham; Mollaghasemi, Negar; Rezaei, Sheyda; Arab, Arman

doi:10.1186/s12610-021-00147-3

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Europe and Asia are also undergoing rapid development and are represented by the University of Southampton and Tehran University of Medical Sciences, respectively. Tehran University of Medical Sciences paid more attention to the role of vitamin D in male reproduction ( 88 – 90 ) and the mechanism by which vitamin D improved female reproductive disorders including endometriosis ( 91 , 92 ), PCOS ( 93 , 94 ), repeated implantation failure ( 51 , 95 ), and endometritis ( 96 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

Zhang

et al. 2022

Front. Nutr.

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BackgroundVitamin D plays an invaluable role in reproductive health, but vitamin D insufficiency and deficiency are generally common among couples of childbearing age and pregnant women. This study aimed to evaluate the evolution, development trend, and research hotspot of publications on vitamin D and reproductive health.MethodsThe literature on vitamin D and reproductive health between 2012 and 2021 was retrieved from the Web of Science Core Collection (WoSCC). We used VOSviewer and CiteSpace to analyze publication years, countries, institutions, journals, highly cited authors and publications, and co-occurrence and citation bursts of keywords.ResultsA total of 1,828 articles and reviews on vitamin D and reproductive health published between 2012 and 2021 were identified. The annual publication outputs showed steady growth, with the most publications (272) and citations (7,097) in 2021. The United States contributed the most publications (458) and had the highest h-index (58). In terms of the number of publications and h-index, the journal named Nutrients ranked first. Nutrition dietetics, obstetrics gynecology, and endocrinology metabolism were three well-represented disciplines in research on vitamin D and reproductive health. Hollis BW, Wagner CL, and Litonjua AA were the top three most productive authors in this field during the last decade. Apart from vitamin D, the five keywords with the most frequent occurrence were vitamin D deficiency, pregnancy, risk, vitamin D supplementation, and 25-hydroxyvitamin D. Keyword citation burst analysis revealed that low birth weight, adipose tissue, marker, and embryo had a citation burst lasting until 2021.ConclusionIn conclusion, vitamin D has received continuous attention in the field of reproductive health, and there appears to have a higher level of research in North America. Multidisciplinary intersection contributed to the in-depth exploration in this field. And the effect of maternal vitamin D levels on fetal lipid metabolism and the prediction of fertility by vitamin D-related markers might be hotspots for the research.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

Zhang

et al. 2022

Front. Nutr.

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Causal association between 25-Hydroxyvitamin D and risk of abnormal spermatozoa: A bidirectional Mendelian randomization study

Li,

Yang,

Zeng

et al. 2024

Reproductive Toxicology

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The Association between Serum Vitamin D Levels and Male Fertility: A Systematic Review and Meta-Analysis

Yan,

Qi,

et al. 2023

Andrologia

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Objective. The probable relationship between serum vitamin D levels and male fertility is being increasingly investigated; however, the findings have been controversial. This review dealt with assessing the relationship between serum vitamin D levels and male fertility and sperm quality by executing systematic review and meta-analysis of the published data. Methods. The meta-analysis was executed as per the PRISMA 2020 statement. The protocol was registered with PROSPERO (CRD42022327583). Relevant literature was retrieved by searching online databases, including Embase, Scopus, PubMed, Web of Science, and the Cochrane Library, up to December 1st, 2022. Additionally, Google Scholar was searched to assess relevant articles. To ensure a more comprehensive review, unpublished articles, gray literature, and references of suitable articles were also assessed to find additional eligible publications. The articles that satisfied the inclusion criteria were evaluated for their quality using the Joanna Briggs Institute Critical Appraisal Tool. Meta-analysis was conducted through STATA 12. Results. Twenty-four articles, comprising 7,345 participants in total, were chosen for the systematic review and meta-analysis. The resulting data indicated that serum vitamin D levels infertile males were remarkably elevated compared with that in infertile males (weighted mean difference (WMD) = 7.06, 95% confidence interval (95% CI) = 2.51–11.62, P = 0.002 ), and its deficiency (<20 ng/mL or 50 nmol/L) significantly reduced sperm concentration (WMD = 8.54, 95% CI = 4.01–13.06, P < 0.001 ), total sperm count (WMD = 14.43, 95% CI = 1.30–27.55, P = 0.031 ), sperm motility (WMD = 6.40, 95% CI = 3.15–9.64, P < 0.001 ), sperm progressive motility (WMD = 5.00, 95% CI 1.09–8.92, P = 0.012 ), and altered sperm morphology (WMD = 0.74, 95% CI = 0.20–1.27, P = 0.007 ). The data analysis determined that vitamin D did not remarkably influence sperm volume (WMD = 0.17; 95% CI = −0.00–0.34; P = 0.050 ). Conclusion. The acquired data implied that serum vitamin D is significantly associated with male fertility and sperm quality. This finding holds crucial implications for patients suffering from male infertility.

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Is there a relationship between serum vitamin D and semen parameters? A cross-sectional sample of the Iranian infertile men

Cited by 4 publications

References 43 publications

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

Causal association between 25-Hydroxyvitamin D and risk of abnormal spermatozoa: A bidirectional Mendelian randomization study

The Association between Serum Vitamin D Levels and Male Fertility: A Systematic Review and Meta-Analysis

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