Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.
N e e l e s h M a l v i y a a n d S a p n a Malviya. Bioassay guided fractionation-an emerging technique influence the isolation, identification and characterization of lead phytomolecules.
The present study investigated the antidiabetic potential of Cedrus deodara heart wood aqueous extract and its relationship with its antioxidant properties. Aqueous extract of Cedrus deodara reduces blood sugar level in alloxan induced diabetic rats. Reduction in blood sugar was observed following 5th day onwards after continuous administration of the extract and on 21st day sugar levels were found to be reduced by 40.20%. Oxidative stress produced by alloxan was found to be significantly lowered (P ≤ 0.01) by the administration of Cedrus deodara aqueous extract (500 mg/kg). This was evident from significant decrease (P ≤ 0.01) in lipid per oxidation level in liver induced by alloxan. The levels of Glutathione, Catalase, Superoxide dismutase and Glutathione-S-Transferase in liver, kidney and pancreas tissue were found to be increased significantly (P ≤ 0.01) after drug administration. The results from this study suggest that the Cedrus deodara aqueous extract effectively and significantly reduced (P ≤ 0.01) the oxidative stress induced by alloxan and produced a reduction in blood sugar level.
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