Antidiabetic Activity of <I>Cedrus deodara</I> Aqueous Extract and Its Relationship with Its Antioxidant Properties

Abstract

The present study investigated the antidiabetic potential of Cedrus deodara heart wood aqueous extract and its relationship with its antioxidant properties. Aqueous extract of Cedrus deodara reduces blood sugar level in alloxan induced diabetic rats. Reduction in blood sugar was observed following 5th day onwards after continuous administration of the extract and on 21st day sugar levels were found to be reduced by 40.20%. Oxidative stress produced by alloxan was found to be significantly lowered (P ≤ 0.01) by the administration of Cedrus deodara aqueous extract (500 mg/kg). This was evident from significant decrease (P ≤ 0.01) in lipid per oxidation level in liver induced by alloxan. The levels of Glutathione, Catalase, Superoxide dismutase and Glutathione-S-Transferase in liver, kidney and pancreas tissue were found to be increased significantly (P ≤ 0.01) after drug administration. The results from this study suggest that the Cedrus deodara aqueous extract effectively and significantly reduced (P ≤ 0.01) the oxidative stress induced by alloxan and produced a reduction in blood sugar level.

Experimental evaluation of hypnotic and antidepressant effect of pine needles of Cedrus deodara

“…The phytochemical studies on CD have reported that majority of phytoconstituents are present in the wood and needles of CD [ 43 ]. Heartwood and stem bark of CD have been used in experimental animals for evaluating anticancer, analgesic, anti-inflammatory, hypolipidemic, anti-diabetic, gastroprotective and anti-epileptic activities [ 31 , [44] , [45] , [46] ]. In most of the previous experimental studies, the alcoholic extract of either heartwood or stem bark of CD has been used.…”

“…The dose chosen of the alcoholic extract for evaluating antidepressant effect in rats was 100 mg/kg. This dose was selected from the previous preclinical study which evaluated 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione (BDFD) of heart wood in the experimental model of depression [ 24 ] The doses of the aqueous extract in the depression model: 250 and 500 mg/kg were chosen from the experimental study which used the aqueous extract of heartwood of CD in the model of antidiabetic study [ 31 ]. Two doses of the aqueous extract used in mice for testing hypnotic effect were 50 and 100 mg/kg.…”

“…Rats were randomly divided into five groups of eight animals each in stage 1. The study groups were as follows: Vehicle control (Saline -5 ml/kg i.p), Standard control (Fluoxetine - 5 mg/kg i.p) [ 29 , 30 ], two doses of Aqueous extract of CD (250 & 500 mg/kg i.p) [ 31 ] and one dose of Alcoholic extract of CD (100 mg/kg i.p) [ 24 ].…”

Potential Role of Darvyadi Kwatha in the Management of Diabetes

“…12 The and substantially reduced alloxan-induced oxidative stress and produced a decrease in BGL. 13…”

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“…In addition, it was also observed that treatment of rats with aqueous wood extract over a study period of 21 days resulted in a dosedependent decrease in TBARS along with restoration of superoxide dismutase (SOD), catalase, glutathione (GSH), and glutathione S-transferase to normal levels. [48] α-amylase inhibitory activity…”