Aim of this work is to verify the effect of some neurotoxins, physical factors and geography in presentation of some Relevant Neurological disorder like some form of ASL, PD, AD. The geographic diffusion of the ASL/PD in west pacifi c (GUAM foci), and mutation of SOD 1 and other mutations are interesting facts to verify the recent literature about the neurotoxic process. Related to the references presented a global conclusion about the pathogenetic progression of some neurological disease will be produced as instrument for new hypothesis and for the introduction of new innovative therapeutic strategies.

Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro-environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local microenvironment status as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (Reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).

In this work is analyzed scientific literature involved in human evolution to be used as an archeological pathway to link different sciences in an overall new discipline. A rational classification of single evidence make possible to better understand under new light some physiological process. The archeological instrument to be applied in other field like biology or other sciences.

extracellular matrix (ECM) proteins, fibrosis results in scarring and thickening of the interested tissue, it is in essence an exaggerated wound healing response that interferes with normal organ functionality. (is similar to the scarring phenomena, involve stimulated fibroblasts laying down connective tissue, including collagen and glycosamino-glycans. The process start when the immune-cells (macrophages) release the soluble factors that stimulate the fibroblasts population. Pro-fibrotic mediator is the TGF beta, released by macro-phages and by any damaged tissue between surfaces named interstitium. Other mediators involved: CTGF, platelet-derived growth factor (PDGF), interleukin 4. These start the signal transduction pathways like s AKT/mTOR, SMAD pathways that ultimately lead to the proliferation -activation of the

In some non-voluntary crime is crucial verify the amygdala and limbic system physiopathology of human responsible of the facts under Jurisdictional contest. But is relevant to verify this condition in objective way. Many human physio-pathological conditions are deeply investigated using biochemical or imaging technique is possible that today many organ and system are currently evaluated with high number of biomedical, instrumental or imaging test also In basal or stressing condition. The objective setting of amygdala and limbic system must be added in jurisdictional procedure not as a prove but an additional information to be correctly evaluated.

This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000563.The amygdala is responsible for deciding what memories are stored and where they are stored. The level of emotion that is attached to a memory determines where it is stored in the CNS. When faced with a threatening situation, thalamus, which receives incoming stimuli, sends signals to the amygdala and the cortex. If amygdala senses danger, it makes a split second decision and

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