Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro-environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local microenvironment status as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (Reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).

Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and infl ammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem and the process. Scope of this project is to submit to the researcher a new therapeutic strategy (under a depurative-toxicological-pharmacological) in this complex kind of disease. A Turing machine theory say us a method to TRASLATE the need of a strategy in a practical hypotesys of work. A global conceptual map can help in this fi eld.

Brazil's Amazon, official COVID-19 toll under scrutinyBy Jake Spring, Eduardo Simões, Bruno Kelly: The largest of 9 states in Brazil's Amazon rainforest, Amazonas has registered nearly 19.4 coronavirus-deaths per 100,000 residents, compared to 4.4 for all of Brazil, according to a Reuters-calculation based on the death toll released by the federal Health-Ministry on Thursday. The corona virus COVID-19 killed 422 people in Amazonas in April, according to the ministry. Yet death registry data from public-notaries indicates the ministry's statistics may far underestimate the actual toll." The Guardian, Jan 2021: Covid-19 eruption in Brazil's largest state leaves health workers begging for help. Amazonas, and particularly its riverside-capital Manaus, were pummeled by the epidemic's first-wave last April, when authorities were forced to dig mass graves for victims" And from: Monitoring air pollution from fires 09/09/2019 ESA / Applications / Observing the Earth / Copernicus / Sentinel-5P The wildfires that have been devastating the Amazon-rainforest

Before actual COVID-19 pandemia coronavirus was not so dangerous like now. In December 2019 - January 2020 in Wuhan first and then in other places this coronavirus was responsible of a first wave of severe pulmonitis responsible of many deaths. Wuhan and other region involved first was high level air polluted and industrial area. New COVID-19 variant in last part of 2020 and in first month of 2021 was responsible of great diffusion of this pandemic disease. UK, South Africa and brasilian new variant show higher diffusion then the first wave of COVID-19. Aim of this work is to analyze relationship with air pollution and the possibility that mutagen substantia inside of this microenvironment can produce new variant trough an genetic pressure process. RNA viruses are normally subjected by natural mutation but some phenomena can contribute to accelerate this process and their airborne – aeresols microenvironment is relevant. Some air pollutants are recognized as mutagen factors by literature.

alterations, non-hypermutated tumors. 3.CpG island methylator phenotype (CIMP) is related to aberrant methylation in several genes, in sporadic cases with DNA mismatch repair pathway deficient (dMMR) and MSI-high tumors. BRAF mutations are also commonly observed within this last phenotype.