Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, Alzheimer Disease and other Neurodegenerative Diseases

Abstract

Aim of this work is to verify the effect of some neurotoxins, physical factors and geography in presentation of some Relevant Neurological disorder like some form of ASL, PD, AD. The geographic diffusion of the ASL/PD in west pacifi c (GUAM foci), and mutation of SOD 1 and other mutations are interesting facts to verify the recent literature about the neurotoxic process. Related to the references presented a global conclusion about the pathogenetic progression of some neurological disease will be produced as instrument for new hypothesis and for the introduction of new innovative therapeutic strategies.

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

“…Amyotrophic lateral sclerosis is an irrev ersible neurodegenerative disorder that quickly progresses and causes the erosion of motor neurons not only within the brain but also throughout the spinal cord [192][193][194]. In addition, ALS is accompanied by the reduction and dysfunction of upper motor neurons [48,195,196].…”

“…It has been disc overed that ALS patients have mutations in the gene encoding the antioxidant enzyme superoxide dismutase 1 (SOD1) [202]. Mutant SOD1 leads to aggregation in motor neurons within the CNS [193]. Other causes include oxidative stress, neuroin lammation, glutamate excitotoxicity, changes in neuro ilaments, mitochondrial degeneration and damage, protein aggregation, apoptosis, and de iciencies in factors related to growth [46,[203][204][205].…”

“…Fiber, vitamin E, and omega-3 fatty acids can also potentially impart lasting bene its in ALS [193]. A study comprising 132 ALS patients and 220 healthy controls showed that high consumption of vitamin E, in conjunction with omega-3 fatty acids, reduced the risk of developing ALS by as much as 50%-60% [218].…”

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

“…A high prevalence of capillaries allows for quick diffusion of reactants and products of respiration, and increases the possibility that other contents in the blood may diffuse across the capillary wall. The BBB evolved to allow for a higher rate of selectivity for what may pass through to the brain tissue to help preserve and protect the brain from possible detrimental molecules or organisms in the blood [1,2]. Scope of this article is to verify some relevant condition involving the "SNC washing system" that can be useful in some neurodegenerative or in lammatory (but also acute trauma) pathology.…”

“…The same also using the same liquid medium we can observe if present an intrinsic weakness of the nerve tissue affected vs normal tissue. In this experimental project we can show even intrinsic interesting verify ALSO if using a medical device system is possible to get a more persistence of activity of the measure adopted (pharmacological depurative-detoxicant or with other mechanism that can improve the persistence of action in local spinal cord)" [2].…”