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These analysis will provide a critical evidence that 1,2-diazole could provide a new protective strategy against cisplatin-induced nephrotoxicity.

Effect of Acacia nilotica Against Dalton's Ascitic Lymphoma ModelAsian Pacific J Cancer Prev, 13, 3989-3995 IntroductionOver the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. World Health Organization (WHO) reported that there are 7.6 million deaths in 2008 and it is estimated up to 13.1 million deaths in 2030 (Merel et al., 2012). Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Currently cancer is treated using surgery, radiation, and chemotherapy which are associated with severe side effects (Garcia et al., 2001;Edy et al., 2012). Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditionally used large number of medicinal plants and plant products has become the potential source of antitumor agents. Traditional healers of different regions in India particularly Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010

The potential biological functions of A. nilotica have long been described in traditional system of medicine. However, the protective effect of A. nilotica on acetaminophen-induced hepatotoxicity is still unknown. The present study attempted to investigate the protective effect of A. nilotica against acetaminophen-induced hepatic damage in Wistar rats. The biochemical liver functional tests Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), total bilirubin, total protein, oxidative stress test (Lipid peroxidation), antioxidant parameter glutathione (GSH), and histopathological changes were examined. Our results show that the pretreatment with A. nilotica (250 mg/kg·bw) orally revealed attenuation of serum activities of ALT, AST, ALP, liver weight, and total bilirubin levels that were enhanced by administration of acetaminophen. Further, pretreatment with extract elevated the total protein and GSH level and decreased the level of LPO. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by acetaminophen. The present study undoubtedly provides a proof that hepatoprotective action of A. nilotica extract may rely on its effect on reducing the oxidative stress in acetaminophen-induced hepatic damage in rat model.

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