Bauhenia tomentosa Stimulates the Immune System and Scavenges Free-Radical Generation in vitro and in vivo

Kannan, Narayanan; Renitta, R. Emilin; Guruvayoorappan, Chandrasekharan

doi:10.1515/jbcpp.2010.21.2.157

Cited by 11 publications

(6 citation statements)

References 10 publications

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“…Previous studies from our laboratory showed that B. tomentosa preparations appeared to impart various biological effects, such as acting as an immunomodulant, as well as imparting anti-oxidant, anti-inflammatory, and anti-tumor growth effect (in vitro only). (Kannan et al, 2010). The present study showed there was an anti-tumor effect induced by a B. tomentosa extract in vivo, in both an ascites and a solid tumor model.…”

Section: Discussionsupporting

confidence: 61%

“…Bauhinia tomentosa has been reported to impart antioxidant (Mannangatti et al, 2010), -diabetes (Devaki et al, 2011), and -microbial effects (Gopalakrishnan and Vadivel, 2011). Preparations of B. tomentosa have been shown to stimulate the immune system and act as potential anti-inflammatory agents (Kannan et al, 2010). Aderogha et al (2008) reported the ethanolic extract of B. tomentosa leaves contain significant levels of campferol-7-O-rhamnoside, campferol-3-O-glucoside, quercetin-3-O-glucoside, and quercetin-3-O-rutinoside.…”

Section: Anti-tumor and Chemoprotective Effect Of Bauhinia Tomentosa By Regulating Growth Factors And Inflammatory Mediatorsmentioning

confidence: 99%

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Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Kannan

Sakthivel²,

Guruvayoorappan³

2016

Asian Pacific Journal of Cancer Prevention

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of cancer and autoimmune disorders (Haque et al., 2003). CTX has been reported to disturb fundamental mechanisms concerned with cell growth differentiation and function (Alenzi et al., 2010), this chemotherapeutic has also been reported to induce several toxic side effects like nausea, fatigue, hair loss, and to cause reduction in host levels of immune cells (Kiuchi et al., 2009). Due to the toxic side effects of CTX, the need for new drugs effective

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Section: Discussionsupporting

confidence: 61%

Section: Anti-tumor and Chemoprotective Effect Of Bauhinia Tomentosa By Regulating Growth Factors And Inflammatory Mediatorsmentioning

confidence: 99%

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Kannan

Sakthivel²,

Guruvayoorappan³

2016

Asian Pacific Journal of Cancer Prevention

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“…The methanolic extract of Bauhinia tomentosa was evaluated for its immunomodulatory, anti-oxidant and anti-inflammatory activity [16] in BALB/c mice. Methanolic extract of Bauhinia tomentosa is administered intra peritoneally and observed for total leukocyte count, bone marrow cellularity and αesterase positive cells and compared with control groups.…”

Section: Anti-oxidant/ Immunomodulatory/ Antiinflammatorymentioning

confidence: 99%

Bauhinia Tomentosa: A Review

Nallabattini¹,

Kuttiappan²,

Kasimedu³

2015

JCP

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Bauhinia tomentosa is commonly known as yellow bauhinia, yellow orchid tree and yellow bell orchid tree. It is an erect, branched shrub belonging to the family Fabaceae. The plant is reported to contain proteins, amino acids, fatty acids, minerals, alkaloids, flavonoids, phyto steroids, saponins, tannins, phenolic compounds, fixed oils and fats. Pharmacological studies proved its anti-oxidant, anti-bacterial, anti-hyperglycemic, anti-lipidemic, anti-ulcer, immunomodulatory, anti-diarrhoeal, anti-microbial and anti-diabetic activities. This review presents a detailed survey on therapeutic uses, chemical constituents and pharmacological activities of Bauhinia tomentosa.

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“…The genus Bauhinia is a member of the Leguminosae family (subfamily Caesalpiniaceae) and consists of about 300 species. Bauhinia tomentosa is a South Indian shrub that has been applied in ayurvedic medicine for centuries based on its multiple beneficial effects, including antioxidant, anti-inflammatory, antitumor, antimicrobial, antiamoebic, antidiabetic, and antirheumatic properties as well as functioning as an analgesic and hypocholesterolemic agent [ 35 , 36 , 37 , 38 , 39 ]. Additionally, its extracts contain a diverse set of metabolites that could be possibly used in the reduction of silver ions, as a capping and stabilizing agent in the synthesis of nanoparticles [ 35 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antifungal, and Antioxidant Activities of Silver Nanoparticles Biosynthesized from Bauhinia tomentosa Linn

Senthil¹,

Subramaniyan²,

Karunanithi³

et al. 2021

Antioxidants

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The biogenic synthesis of silver nanoparticles (AgNPs) has a wide range of applications in the pharmaceutical industry. Here, we synthesized AgNPs using the aqueous flower extract of Bauhinia tomentosa Linn. Formation of AgNPs was observed using ultraviolet-visible light spectrophotometry at different time intervals. Maximum absorption was observed after 4 h at 420 nm due to the reduction of Ag+ to Ag0. The stabilizing activity of functional groups was identified by Fourier-transform infrared spectroscopy. Size and surface morphology were also analyzed using scanning electron microscopy. The present study revealed the AgNPs were spherical in form with a diameter of 32 nm. The face-centered cubic structure of AgNPs was indexed using X-ray powder diffraction with peaks at 2θ = 37°, 49°, 63°, and 76° (corresponding to the planes of silver 111, 200, 220, 311), respectively. Energy-dispersive X-ray spectroscopy revealed that pure reduced silver (Ag0) was the major constituent (59.08%). Antimicrobial analyses showed that the biosynthesized AgNPs possess increased antibacterial activity (against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), with larger zone formation against S. aureus (9.25 mm) compared with that of E. coli (6.75 mm)) and antifungal activity (against Aspergillus flavus and Candida albican (with superior inhibition against A. flavus (zone of inhibition: 7 mm) compared with C. albicans (zone of inhibition: 5.75 mm)). Inhibition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was found to be dose-dependent with half-maximal inhibitory concentration (IC50) values of 56.77 μg/mL and 43.03 μg/mL for AgNPs and ascorbic acid (control), respectively, thus confirming that silver nanoparticles have greater antioxidant activity than ascorbic acid. Molecular docking was used to determine the mode of antimicrobial interaction of our biosynthesized B. tomentosa Linn flower-powder extract-derived AgNPs. The biogenic AgNPs preferred hydrophobic contacts to inhibit bacterial and fungal sustainability with reducing antioxidant properties, suggesting that biogenic AgNPs can serve as effective medicinal agents.

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Bauhenia tomentosa Stimulates the Immune System and Scavenges Free-Radical Generation in vitro and in vivo

Cited by 11 publications

References 10 publications

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Anti-tumor and Chemoprotective Effect of Bauhinia tomentosa by Regulating Growth Factors and Inflammatory Mediators

Bauhinia Tomentosa: A Review

Antibacterial, Antifungal, and Antioxidant Activities of Silver Nanoparticles Biosynthesized from Bauhinia tomentosa Linn

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