Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators

Kannan, Narayanan; Guruvayoorappan, Chandrasekharan

doi:10.1016/j.intimp.2013.03.008

Cited by 72 publications

(47 citation statements)

References 47 publications

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“…Similar to previous studies [14], [29], DSS decreases colonic T-SOD activity in mice. Arginine supplementation reverses this decline at day 12 in DSS-induced colitis model, which may explain the beneficial role of arginine supplementation on colonic oxidative injury caused by DSS in mice.…”

Section: Discussionsupporting

confidence: 91%

“…Oxidative stress has been involved in the pathogenesis of inflammatory bowel disease, and investigations have found that the inflamed mucosa increases the production of reactive oxygen metabolities, such as superoxide, hydroxyl radical and hydrogen peroxide [14]. Thus, we detected some factors in anti-oxidative system, including catalase, T-SOD and GSH-Px.…”

Section: Resultsmentioning

confidence: 83%

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Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis

et al. 2014

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This study was conducted to investigate serum amino acids profile in dextran sulfate sodium (DSS)-induced colitis, and impacts of graded dose of arginine or glutamine supplementation on the colitis. Using DSS-induced colitis model, which is similar to human ulcerative colitis, we determined serum profile of amino acids at day 3, 7, 10 and 12 (5 days post DSS treatment). Meanwhile, effects of graded dose of arginine (0.4%, 0.8%, and 1.5%) or glutamine (0.5%, 1.0% and 2.0%) supplementation on clinical parameters, serum amino acids, colonic tight junction proteins, colonic anti-oxidative indicators [catalase, total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px)], colonic pro-inflammatory cytokines [interleukin-1 beta (IL-1β), IL-6, IL-17 and tumor necrosis factor alpha (TNF-α)] in DSS-induced colitis were fully analyzed at day 7 and 12. Additionally, the activation of signal transduction pathways, including nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPK), phosphoinositide-3-kinases (PI3K)/PI3K-protein kinase B (Akt), and myosin light chain kinase (MLCK)- myosin light chain (MLC20), were analyzed using immunoblotting. Serum amino acids analysis showed that DSS treatment changed the serum contents of amino acids, such as Trp, Glu, and Gln (P<0.05). Dietary arginine or glutamine supplementation had significant (P<0.05) influence on the clinical and biochemical parameters (T-SOD, IL-17 and TNF-α) in colitis model. These results were associated with colonic NF-κB, PI3K-Akt and MLCK signaling pathways. In conclusion, arginine or glutamine could be a potential therapy for intestinal inflammatory diseases.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 83%

Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis

et al. 2014

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“…Because the pathomechanism of oxidative stress in IBD has been suggested by many laboratory reports and clinical trials, regulating Nrf2 signaling and suppressing ROS generation by targeting NOX or mitochondria are both potential treatment options for IBD. Furthermore, some nonconventional therapeutic methods with antioxidant effects, such as ROS generation inhibitors, hormones, functional dietary interventions, and natural or synthetic substances that inhibit cell death and activate antioxidant enzymes, have attracted increasing attentions as complementary and alternative medicines (CAMs) for IBD [183, 184]. These antioxidant therapies may have fewer side effects, lower costs, and better treatment responses, offering new hopes to IBD patients, especially those with UC in both the active phase and the remission stage of the disease [185].…”

Section: New Therapies Targeting Oxidative Stress In Ibdmentioning

confidence: 99%

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Tian

Wang

Zhang

2017

Oxidative Medicine and Cellular Longevity

431

363

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Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of IBD. This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response. In addition, potential therapeutic strategies for IBD that target oxidative stress signaling are reviewed and discussed. Though substantial progress has been made in understanding the role of oxidative stress in IBD in humans and experimental animals, the underlying mechanisms are still not well defined. Thus, further studies are needed to validate how oxidative stress signaling is involved in and contributes to the development of IBD.

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“…Subsequently, using a medical-grade polyurethane tube for enteral feeding (external diameter 2 mm), 1~2 ml of (3~4%) acetic acid is instilled 6~8 cm proximal to the anus verge. Eventually, after 15~30 s of exposure the fluid is withdrawn and animals are sacrificed and their blood and colons are collected 24~48 hrs after induction of colitis for carrying out various histopathological and biochemical investigations [25,26,89,97,106,107,108]. Other scientists have revealed that intracolonic administration of 4 ml of 4 % acetic acid at a dose 5 ml/kg also leads to induction of colitis in rats [99,109,110,111,112].…”

Section: Chemical Induced Models Of Chronic Intestinal Inflammationmentioning

confidence: 99%

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

Randhawa

Singh

et al. 2014

Korean J Physiol Pharmacol

357

310

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Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain, development of various animal models provides new insights to unveil the onset and the progression of IBD. Various chemical-induced colitis models are widely used on laboratory scale. Furthermore, these models closely mimic morphological, histopathological and symptomatical features of human IBD. Among the chemical-induced colitis models, trinitrobenzene sulfonic acid (TNBS)-induced colitis, oxazolone induced-colitis and dextran sulphate sodium (DSS)-induced colitis models are most widely used. TNBS elicits Th-1 driven immune response, whereas oxazolone predominantly exhibits immune response of Th-2 phenotype. DSS-induced colitis model also induces changes in Th-1/Th-2 cytokine profile. The present review discusses the methodology and rationale of using various chemical-induced colitis models for evaluating the pathogenesis of IBD.

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Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators

Cited by 72 publications

References 47 publications

Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis

Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

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