Chicken pox in the Russian Federation in recent years has maintained a consistently high level of rating in the structure of infectious diseases and the magnitude of economic damage from infectious diseases.Purpose:was to assess the epidemiological features of chicken pox in adults over 18 years in the Voronezh region.Methods.Materials the study was of the form of Federal state statistical supervision over 2006 – 2017 years. The method of retrospective epidemiological analysis was used. Statistical data processing was performed using Microsoft Excel.Results.In recent years, in the Voronezh region there has been an increase in the incidence and hospitalization of adults diagnosed with varicella. In persons older than 18 years, more severe course and complications were observed. Cases of varicella were reported as an infection related to medical care. The sources of infection for nosocomial cases were pregnant women and healthcare professional.Conclusions.In order to prevent introduction and spread of chicken pox in medical organizations of the region it is necessary to consider the immunization of contingents at risk. It requires the introduction of a permanent statistical monitoring of individuals with a diagnosis of «Shingles».

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Adaptive potential is an indicator of the level of adaptability of the human body to various and changing environmental factors. The adaptive capabilities of the body are influenced not only by external factors, but also by internal - the state of the body as a whole, by the presence or absence of chronic diseases. Therefore, the adaptive potential was used as an integral indicator of a person's adaptability to production factors. The aim of the study was to assess the adaptive capabilities of the organism of workers in greenhouse farms in the Voronezh region. The study was carried out at the enterprises of the closed ground of the region by the method of questioning, the objects of the study were 125 women aged 27-45 years. In most cases, there are violations of the adaptive capabilities of the organism among the studied workers of greenhouse farms, and even a breakdown in adaptation was revealed in 0.8%. In less than half of the cases, the adaptive potential of the greenhouses was within the normal. The adaptive reserves of the greenhouses workers decrease with age.

According to the results of the study, it was found that from 15.10.20 to 21.10.20. -the time of the beginning of the second wave of the rise in morbidity -significantly more often in public transport people observed the mask regime, but a third were without masks (p <0.0001). From 22.10.20 to 28.10.20 -the period of transfer of schoolchildren and students of the city to a distance learning format -reliably more often people in public transport were without masks (p <0.0001).The change in the structure of observance of the mask regime in public transport, on the one hand, can be explained by a sharp decrease in passenger traffic, the lack of control by drivers (cashiers), on the other hand, by the lack of commitment of city residents to comply with the requirements of sanitary legislation.

Background: To increase public confidence in vaccine prevention and to actually assess the safety of vaccines against COVID-19, it is necessary to study the frequency and structure of adverse events after immunization in the post-registration period of vaccine use. Aim: is to assess the frequency and structure of adverse events after immunization against COVID-19 among young people. Materials and methods: a single center cross-sectional study was conducted based on a questioning of 333 respondents aged 1825 years (76.88% female, 23.12% male). The questionnaire included 2 groups of questions: general and special (nature of post-vaccination reactions, history of COVID-19 disease before and after vaccination). Statistical processing of the results was carried out using standard Microsoft Office Excel 2016 software packages. Results: The most common complaints after vaccination were soreness at the injection site (57.66%), weakness (54.65%) and body aches (24.92%). There were local and general/combined (weak, moderate, strong) reactions, they were observed in 30.93% of respondents after 1 dose and 45.35% after 2 doses. In the structure of reactions after the first immunization, general weak reactions (15.32%, p=0.001) were significantly more common than others (15.32%, p=0.001), after the second - local ones (21.92%, p0.0001). A strong correlation was established between responses to the 1st and 2nd doses of the vaccine (r=0.94, p0.0001). When studying the frequency and structure of post-vaccination reactions in gender groups and in those who had COVID-19 before vaccination and those who did not, no significant differences were found. Conclusion: The study found that among young people, the majority did not have objective reactions after immunization against a new coronavirus infection. General weak and local reactions were more common among the objective post-vaccination reactions.

Изучение этиологической структуры возбудителей инфекций мочевых путей и их чувствительности к антибиотикам необходимо для обеспечения адекватной антибактериальной терапии. Целью исследования было изучение чувствительности к антимикробным препаратам штаммов Escherichia coli, выделенных от пациентов с мочекаменной болезнью. Материалом исследования были 500 историй болезней пациентов с обострением мочекаменной болезни, госпитализированных в скоропомощные стационары г. Воронежа за период 2017-2019 гг. Всем пациентам проводилось общеклиническое обследование с бактериологическим исследованием мочи. Критерием включения пациентов в исследование был положительный результат бактериологического посева мочи в период госпитализации с выделением Escherichia coli. Проведенное исследование показало, что у пациентов с мочекаменной болезнью и с признаками инфекции мочевых путей кишечная палочка была обнаружена в 42,4% случаях. Всего 29,7% штаммов кишечной палочки были чувствительны ко всем исследованным антибиотикам, 70,3% штаммов имели различные фенотипические варианты резистентности: 15,6%были устойчивы к одной группе антимикробных препаратов, 25,5%-к двум группам, и 29,2% имели множественную антибиотикорезистентность. В структуре штаммов E. coli с монорезистентностью чаще имела место устойчивость к ампициллину и цефтриаксону; с полирезистентностью-к комбинации аминогликозидов с цефалоспоринами. Среди выделенных изолятов E. coli с фенотипом множественной лекарственной устойчивости преобладающее большинство штаммов (53,3%) имело резистентность к комбинации аминогликозидов, пенициллинов, фторхинолонов и цефалоспоринов, второе место заняла комбинация пенициллинов, фторхинолонов и цефалоспоринов. Ключевые слова: Escherichia coli, инфекция мочевых путей, мочекаменная болезнь, чувствительность к антибиотикам, антибиотикорезистентность.

Background: Numerous studies have demonstrated a steadily growing trend in the prevalence of obesity around the world. The objective of this study was to assess obesity incidence rates among various age groups of the population of the Voronezh Region in 2010–2017. Materials and methods: We used official data of the Voronezh Regional Information Fund, Registration Form No. 12 of the Russian Federal State Statistics Service, as well as outpatient cards and medical histories of 685 adults and 269 adolescents. Results: We established that the number of obese adults prevailed. The study period of 2010–2017 was characterized by a steady increase in the incidence and prevalence rates of obesity across all age groups of the population: we observed a 1.5, 2.6 and 4.5-fold rise of the incidence rates in children, adolescents and adults, respectively; the percent increase in the prevalence rates was slightly lower and amounted to 34.51% in children, 70.09% in adolescents, and 146.50% in adults. The highest obesity rates were registered among adolescents: 5.02% of them were obese and the study of a random sample confirmed the official statistics. At the same time, the results of the random obesity study in adults demonstrated a tenfold excess of the registered rate. Ranking of the territory of the Voronezh Region by obesity prevalence rates and the analysis of long-term average rates of increase in overall morbidity over the study period showed uneven distribution of obesity by administrative districts of the region in all population groups. Conclusions: The study demonstrated a pronounced upward trend in the incidence of obesity in all population groups of the Voronezh Region and underreporting of this pathology in the adult population of the region. Both findings indicate the need for immediate evidence-based actions aimed at managing the incidence based on data on the actual prevalence of the pathology, identifying the leading risk factors, adjusting diet and physical activity of various population groups, and assessing the efficiency of preventive measures.

The aim of the work was to study the history of the formation of the sanitary service in the Voronezh region in the XVIII–XIX centuries. The material of the research was archival materials of the State Archives of the Voronezh Region, the Voronezh Regional Universal Scientific Library named after I.S. Nikitin. The article presents the main historical stages in the development of the sanitary and epidemiological service of the period of the 18th — 19th centuries. Brief information about the first doctors on the territory of the Voronezh province, the raging epidemics of scurvy, typhus, and plague is presented. The most terrible disease that the population of the Voronezh province faced in the first quarter of the 18th century was the plague. Anti-epidemic measures to combat the plague included the establishment of strong outposts and quarantines on the roads, the burning of houses with belongings, horses and cattle, the delay of couriers and the reception of letters through fire with their three times rewriting, the death penalty if the above measures were violated. In the 18th century, the first hospital for the civilian population was opened in the Voronezh region. Medical institutions were poor, poorly equipped, there was an acute shortage of personnel and medical supplies. In 1797, medical boards were organized in the provincial cities, consisting of an inspector, an obstetrician and an operator. The general supervision of hospitals, keeping records of infectious diseases, monitoring the quality of food, conducting forensic medical examinations, and examining patients was entrusted to the council. In the 19th century, cholera became widespread among the population. To prevent the incidence of smallpox, vaccination of the population was carried out since 1802. At the beginning of the 19th century, the replenishment of medical personnel in the Voronezh province was due to midwives. The situation with medical personnel changed only towards the end of the 19th century. The end of the century is characterized by a significant increase in socially significant infectious diseases, especially tuberculosis, syphilis.