The patients with higher urPSA have higher AGA scores and higher postoperative PSA. This phenomenon is probably the consequence of higher local dihydrotestosterone activity in the scalp and PSA-secreting urethral glands.
U medicinskoj praksi za dijagnostikovanje i prog-nosti~ko pra}enje oboljenja naj~e{}e se koriste laboratorijska dijagnosti~ka odre|ivanja (u daljem tekstu: dijagnosti~ki testovi). Ova dijagnosti~ka strategija uvek je u izvesnoj meri pra}ena nesigurno{}u koja mo`e da potekne od neta~nosti samog dijagnosti~kog testa ili neta~nosti klini~kog sagledavanja stanja pacijenta ili interpretacije dijagnosti~kog testa. Nesigurnost koju uslovljava prvi navedeni uzrok danas je u najve}oj meri smanjena razvojem novih, pogodnijih analiti~kih postupaka i posve}ivanjem vi{e pa`nje sprovo|enju kontrole kvaliteta u laboratorijama. Analiti~ke laboratorijske metode i postupci se danas u najve}oj meri razvijaju za tzv. biomarkere, odnosno biohemijske pokazatelje oboljenja pojedinih organa koji moraju da ima-ju niz specifi~nih karakteristika da bi ispunili uslov da se primene kao biohemijski markeri za otkrivanje i razlikovanje pojedinih oboljenja datog organa. Primenom ovakve definicije pribli`avamo se tzv. organospecifi~nosti nekog biohemijskog parametra koja se primenjuje u klini~koj enzimologiji, mada u organi~enoj meri. Karakteristike biomarkera Uspe{an biohemijski pokazatelj mora da ispuni nekoliko uslova i to: 1) da mu je koncentracija relativno visoka u odgo-varaju}em tkivu, a zanemarljiva u drugim tkivima, 2) da je pogodno subcelularno raspodeljen, kako bi se nakon o{te}enja tkiva brzo na{ao u cirkulaciji, 3) da se u cirkulaciji zadr`ava dovoljno dugo kako bi mogla da se prati njegova koncentracija, 4) da se mo`e odrediti pomo}u pogodne i osetljive analiti~ke metode, primenljive i na automatskim analizatorima, Jugoslov. Med. Biohem. 1
Relative tumor-biopsy volume (RTV) is useful parameter in the preoperative assessment of tumor volume. Patients with higher RTV had significantly higher G and GS. However, these patients had significantly lower uPSA. This phenomenon could be the consequence of compromised PSA drainage from the peripheral zone of the prostate, caused by the tumor.
Higher GAG levels were recorded in all the patients with bladder tumors comparing to samples obtained from healthy individuals. GAG levels do not predict tumor relapse.
The incidence of urinary tract calculosis continuously progresses. The triggering event in the process of stone formation is decreased urinary level of crystallizing inhibitors. The aim of our study was to investigate whether the existing stone or applied therapeutic procedure - extracorporeal shock waves lithotripsy (ESWL) - has effect to urinary levels of Mg, citrate and pyrophosphate. Study included 128 patients with the upper urinary tract stones. ESWL using the Lithostar (Siemens) device was used as a mode of treatment. Out of all patients, 76 (59%) were free of stone particles before 1 month, while 52 (41%) had residual stone fragments even 3 months after ESWL. Mg, citrate and pyrophosphate were measured in 24h-urine specimens: before, between days 2 and 3, as well as 1 and 3 months after ESWL. The analysis of the results revealed that stone itself had no effect on urinary crystallizing inhibitors. Detected increased urinary levels of Mg, citrate and pyrophosphate after ESWL, compared with pre-treatment values, could be attributed to applied therapeutic procedure.
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