Based on the review, we suggest a diagnostic algorithm for nasal liquorrhea. However, the evidence presented in this review is unfortunately not very reliable, which indicates the existing need for more accurate studies.

Rats subjected to isolation significantly more of ten preferred alcohol in the «two-bottle» test after 0.5, 2 and 3 months of forced alcohol drinking. After the end of isolation and before forced alcohol drin-king, the experimental rats showed greater locomotor activity in the «open field» test. According to the exploratory activity and emotionality, the rats in both groups had no significant differences. The rats subjected to isolation, were significantly more sensitive to the sound stimulus and lingered ongerin the start area in the «open field». Thus, the combination of early social isolation and forced alcohol drinking leads to greater alcohol preference in experimental animals. Significant differences in alcohol preference were observed after the start of forced alcohol drinking while immediately after isolation the rats of both groups had no differences in their relation to alcohol. After 3.5 months of forced alcohol drinking, the isolated rats demonstrated decreased behavioral despair in the same test.

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