Background and aims: We investigated the association of dietary intake, particularly fat and its constituent fatty acids, with atherogenic indices in adult patients with overweight, obesity and/or type 2 diabetes (T2D). Material and Methods: Two hundred eighty-five outpatients were selected in two cities located in the Northwestern region of Algeria. Anthropometric measurements for body weight, height, body mass index (BMI) and waist circumference were performed. Relationships between dietary intakes, estimated by a 3- days food record, and fasting blood atherogenic indices - total cholesterol-to-high-density lipoprotein cholesterol ratio (TC/HDL-c) and apolipoprotein (apo) B-to-apo A1 ratio, were analysed. Results: Study group included 58.59% overweight/obese T2D patients, 24.91% normal weight T2D patients and 16.49 % overweight/obese patients without diabetes. Higher dietary consumption (p= 0.003) of total fat, saturated fatty acids (SFAs) and polyunsaturated fatty acids (PUFAs), was recorded in the group of overweight/obese T2D patients. Significant positive correlations were observed between apo B/apo A1 and total fat (p= 0.035), total SFAs (p= 0.042) and palmitic acid (p= 0.042) in the group of overweight/obese T2D patients and with ω6 fatty acid (p= 0.030) in the group of overweight/obese patients without diabetes. In the two groups of T2D patients, whether normal weight, overweight/obese, numerous positive correlations with TC/HDL-c were disclosed for PUFAs, ω6 and fatty acids ratios, namely, ω6/ω3, monounsaturated fatty acids (MUFA)/SFAs and (MUFAs+PUFAs)/SFAs. Conclusion: Most adults, whom are either affected by an excess weight or T2D or both together, are prone to cardiovascular risk. Dietary intakes, particularly in fat and its constituent fatty acids, have an important effect on blood lipid atherogenic indices (TC/HDL-c and apo B/apo A1 ratios).

Background and aims: We designed this study to assess the effect of Ramadan fasting on serum lipid profile among type 2 diabetic patients. Material and Methods: The study was carried out in July 2014 (Ramadan 1421). The total duration of fasting was 17 hours a day. The investigation involved 80 patients. The mean age of the patients was 56± 8 years. The dietary survey lasting three days was recorded. The anthropometric and the biochemical parameters were measured in all subjects before (T1) and during (T2) the fasting month of Ramadan and results were compared using student t-test. Results: There was a significant decrease in high density lipoprotein cholesterol (HDL-c) levels during T2 (0.35±0,08 g/L) compared to T1 (0.38±0,11 g/L). Apolipoprotein A1 (Apo A1) decreased significantly during fasting compared to pre-fasting days while apo B increased during T2 (p˂0.05). The dietary fat consumption increased during Ramadan; especially for the saturated one (p<0.05). Conclusion: The present study suggests that fasting month of Ramadan could be beneficial for some patients with type 2 diabetes who are well controlled and balanced. However, some of them may be at risk of cardiovascular complications in which dyslipidemia can be the leading cause.

BackgroundInfection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.Objective and methodsIn order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as case-control. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL-1RN penta-allelic were genotyped.ResultsIL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR=4.614 [1.43−14.81], p=0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR=4.2 [1.23−3.61], p=0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR=4.286 [1.54−11.89], p=0.005).ConclusionIL-1β and IL-1RN polymorphisms associated with H. pylori infection contribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.

According to our results, cholecystectomy could possibly be a risk factor for pancreatic cancer in Algerian population.

Background and objectiveThe incidence of diabetes co-morbidities could probably be better assessed by studying its associations with major corpulence parameters and glycaemic control indicators. We assessed the utility of body mass index (BMI), waist circumference (WC), and glycosylated haemoglobin (HbA1c) levels in metabolic control for type 2 diabetic patients.MethodsFasting and postprandial blood samples were collected from 238 type 2 diabetic patients aged 57.4±11.9 years. The sera were analysed for glucose, HbA1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and apolipoproteins (apoA-I and apoB). Ratios of lipids and apolipoproteins were calculated and their associations with BMI, WC, and HbA1c levels were analysed.ResultsOur investigation showed increases in most fasting and postprandial lipid parameters according to BMI and WC. In men, postprandial HDL-c and TG levels were significantly higher (p<0.05) in overweight and obese patients, respectively, as well as in patients with abdominal obesity. Contrariwise, postprandial TC levels were significantly higher (p<0.01) in overweight and abdominal obese women. However, elevations of apoA-I and apoB levels were according to BMI and WC in both genders. There was a strong influence of BMI, WC, and HbA1c levels on the apoB/apoA-I ratio compared to traditional fasting and postprandial lipid ratios in both men and women. The apoB/apoA-I ratio was more correlated with postprandial TC/HDL and LDL-c/HDL-c ratios in men and with postprandial TG/HDL-c in women.ConclusionThe apoB/apoA-I ratio is helpful in assessing metabolic risk caused by overall obesity, abdominal obesity and impaired glycaemia in type 2 diabetic patients.

A thematic narrative synthesis was conducted to identify literature exploring the Mediterranean Diet (MDiet) and its impact on the environment in terms of land and water use, Greenhouse Gas emissions, fossil fuels, affordability, and acceptability. The MDiet is a sustainable diet that can reduce some environmental impacts of food production while improving both the health of the population and world, diet acceptability, cost, cultural and socio-economic factors should be considered when determining appropriateness of a recommended dietary pattern to a regional or global population.

Introduction: The magnitude of the healthcare problem of type-2-diabetes increases according to its association with several risk factors for cardiovascular diseases such as obesity and dyslipidemia. Methods: This study took place in the north-western region of Algeria. We aimed to assess the effect of body weight and gender on postprandial lipid and glucose in type-2-diabetes patients. 93 diabetic patients (age 55.65±13.81 years) were studied. Anthropometric parameters and body mass index (BMI) were measured. Fasting and postprandial (PP) glucose and lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, apo A-I and apo B) profiles were evaluated. Results: There were a positive correlation between postprandial glucose and BMI in women (r2 = 0.041). Negative correlation with BMI was noticed for PP TG in both males (r2 = 0.011) and females (r2 = 0.021). A significant difference (p= 0.019) was observed for PP HDL-c in women (0.39 ± 0.10 g/L vs. men 0.33 ± 0.12 g/L) and also for PP apo A-I (women: 1.33 ± 0.27 g/L vs. men: 1.09 ± 0.34 g/L; p= 0.0003). According to gender and weight groups, our results indicated that female gender and overweight are associated with elevated PP HDL-c and PP apo A-I levels. However, obesity in women is related to high concentration of PP TG. Conclusions: The present study suggests that gender difference and weight classes are important factors that contribute to determining the postprandial responses, both for glucose and lipids, in type 2 diabetic patients. Keywords: gender difference; postprandial dyslipidemia; type 2 diabetes; weight groups.

Background: The role of several dietary antioxidants in preventing the development and the progression of atherosclerosis has recently aroused considerable interest. Although they are not yet conclusive, most of the existing suggestions support this hypothesis.Objective: The aim of the present work was to investigate the intake of dietary antioxidant nutrients in relation to atherogenic indices in a group of Algerian middle aged women with and without type 2 diabetes.Methods: A cross-sectional study was conducted on a group of middle-aged women from the north western region of Algeria. Anthropometric and biochemical parameters were measured. Dietary intake was assessed using a validated 3-days food record. Atherogenic indices -total cholesterol-to-high-density lipoprotein cholesterol ratio (TC/HDL) and apolipoprotein (apo) B-to-apo A1 ratio, were calculated. Associations between antioxidants dietary intake and atherogenic indices were examined using logistic regressions.Results: 95 women with type 2 diabetes were compared to 93 non-diabetic ones. Statistical differences (p < 0.05) were revealed for body weight, height, body mass index (BMI), glycosylated hemoglobin (HbA1c) and total cholesterol levels. Furthermore, significant differences were noted for vitamin C, E and copper dietary intakes. The TC/HDL ratio was significantly associated to the highest quartiles of vitamin C in all patients; 3.519[2.405–4.408], p = 0.009 and in non-diabetic women; 3.984[1.775–7.412], p = 0.020, respectively. The odd ratios of vitamin E intakes were about 2.425[2.017–5.715], p = 0.012 in all patients and 1.843[1.877–2.731], p = 0.019 in non-diabetic group, respectively. However, the Apo B/Apo A1 ratio was more correlated to the highest quartiles of zinc and copper in non-diabetic group; OR = 0.059[0.006–0.572], p = 0.015 and 0.192[0.048–0.766], p = 0.019, respectively.Conclusion: The estimated risk of atherosclerosis measured through the TC/HDL ratio was correlated to vitamins antioxidant intake, while the probable risk assessed by the Apo B/Apo A1 ratio was more associated to the mineral profile.