Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected withHelicobacter pyloriin Algeria

Abstract

BackgroundInfection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.Objective and methodsIn order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as case-control. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL-1RN penta-allelic were genotyped.ResultsIL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR=4.614 [1.43−14.81], p=0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR=4.2 [1.23−3.61], p=0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR=4.286 [1.54−11.89], p=0.005).ConclusionIL-1β and IL-1RN polymorphisms associated with H. pylori infection contribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.

Biomarkers of gastric cancer: Current topics and future perspective

“…IL1-β and IL-1RN have a lot of functionally related polymorphism which is associated with the secretion of IL1-β. Existence of IL-1β and IL-1RN polymorphisms with H. pylori infection has been shown to provide the progression of chronic atrophic gastritis and GC in an Algerian population[ 89 ]. To date, advancements of research have proved the importance of SNP in showing individual specific variations of gene aberrations.…”

Interleukin-1β and Cancer

“…Similarly, C/C genotypes may or may not be associated with a higher risk of lung cancer, depending on the studies [ 36 , 37 ]. IL1B-511T carriers, suggesting higher expression of IL1B, present a higher risk of developing gastric cancer [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], or not [ 46 ]. IL1B-511T carriers present a higher risk of developing cervical cancer, acute myeloid leukemia, or chronic myeloid leukemia [ 47 , 48 , 49 , 50 ].…”

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

“…Two articles were added after scanning references lists. In total, 18 articles were included in our meta-analysis [18, 19, 28–43]. Table 1 lists the major characteristics of the included studies.…”